Feasibility Study of the Permeability and Uptake of Mesoporous Silica Nanoparticles across the Blood-Brain Barrier.-论文-万方医学网

第一作者： Habib,Baghirov

第一单位： Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland.

作者： Habib,Baghirov ^[1] ; Didem,Karaman ^[2] ; Tapani,Viitala ^[3] ; Alain,Duchanoy ^[4] ; Yan-Ru,Lou ^[2] ; Veronika,Mamaeva ^[5] ; Evgeny,Pryazhnikov ^[6] ; Leonard,Khiroug ^[2] ; Catharina,de Lange Davies ^[6] ; Cecilia,Sahlgren ^[1] ; Jessica M,Rosenholm ^[7]

作者单位： Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland. ^[1] Laboratory of Physical Chemistry, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland. ^[2] Cell Biology, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland. ^[3] Department of Physics, Norwegian University of Science and Technology, Trondheim, Norway. ^[4] Pharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland. ^[5] Centre for Drug Research, Division of Pharmaceutical Biosciences, University of Helsinki, Helsinki, Finland. ^[6] Neurotar LtD, Helsinki, Finland. ^[7] Eindhoven University of Technology, Eindhoven, The Netherlands. ^[8]

主题词动物(Animals);生物转运(Biological Transport);血脑屏障(Blood-Brain Barrier);脑(Brain);细胞系(Cell Line);细胞存活(Cell Survival);狗(Dogs);药物载体(Drug Carriers);内皮细胞(Endothelial Cells);注射, 静脉内(Injections, Intravenous);小鼠(Mice);显微镜检查, 荧光, 多光子(Microscopy, Fluorescence, Multiphoton);模型, 生物学(Models, Biological);分子显像(Molecular Imaging);纳米粒子(Nanoparticles);粒子大小(Particle Size);通透性(Permeability);聚乙烯二醇类(Polyethylene Glycols);聚乙烯亚胺(Polyethyleneimine);大鼠(Rats);二氧化硅(Silicon Dioxide);表面等离激元(Surface Plasmon Resonance)

DOI 10.1371/journal.pone.0160705

PMID 27547955

发布时间 2022-04-09

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Feasibility Study of the Permeability and Uptake of Mesoporous Silica Nanoparticles across the Blood-Brain Barrier.

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Feasibility Study of the Permeability and Uptake of Mesoporous Silica Nanoparticles across the Blood-Brain Barrier.

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