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首页> Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology> A First-in-Class Small-Molecule that Acts as a Dual Inhibitor of HDAC and PDE5 and that Rescues Hippocampal Synaptic Impairment in Alzheimer's Disease Mice.

A First-in-Class Small-Molecule that Acts as a Dual Inhibitor of HDAC and PDE5 and that Rescues Hippocampal Synaptic Impairment in Alzheimer's Disease Mice.

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作者： Mar,Cuadrado-Tejedor ^[1] ; Carolina,Garcia-Barroso ^[2] ; Juan A,Sánchez-Arias ^[1] ; Obdulia,Rabal ^[3] ; Marta,Pérez-González ^[3] ; Sara,Mederos ^[1] ; Ana,Ugarte ^[4] ; Rafael,Franco ^[3] ; Victor,Segura ^[1] ; Gertrudis,Perea ^[5] ; Julen,Oyarzabal ^[6] ; Ana,Garcia-Osta ^[4]

作者单位： Neurobiology of Alzheimer's Disease, Neurosciences Division, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain. ^[1] Anatomy Department, School of Medicine, University of Navarra, Pamplona, Spain. ^[2] Small Molecule Discovery Platform, Molecular Therapeutics Program, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain. ^[3] Cajal Institute, CSIC, Madrid, Spain. ^[4] Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain. ^[5] Bioinformatics Unit, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain. ^[6]

主题词阿尔茨海默病(Alzheimer Disease);动物(Animals);行为, 动物(Behavior, Animal);疾病模型, 动物(Disease Models, Animal);女(雌)性(Female);海马(Hippocampus);组蛋白脱乙酰基酶抑制剂(Histone Deacetylase Inhibitors);小鼠(Mice);小鼠, 转基因(Mice, Transgenic);运动活动(Motor Activity);神经元可塑性(Neuronal Plasticity);磷酸二酯酶5抑制剂(Phosphodiesterase 5 Inhibitors);吡唑类(Pyrazoles);嘧啶酮类(Pyrimidinones)

DOI 10.1038/npp.2016.163

PMID 27550730

发布时间 2018-11-13

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Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Neuropsychopharmacology

2017年42卷2期

524-539页

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