Identification of a benzo imidazole thiazole derivative as the specific irreversible inhibitor of protein tyrosine phosphatase.

导出原文传递

翻译打印收藏纠错

第一作者： Lin,Ge

第一单位： Key Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, School of Medicine, Shandong University, Jinan, Shandong 250012, China; Department of Physiology, School of Medicine, Shandong University, Jinan, Shandong 250012, China.

作者： Lin,Ge ^[1] ; Kang-Shuai,Li ^[1] ; Meng-Meng,Li ^[2] ; Peng,Xiao ^[3] ; Xu-Ben,Hou ^[4] ; Xu,Chen ^[5] ; Hong-da,Liu ^[2] ; Amy,Lin ^[6] ; Xiao,Yu ^[5] ; Gui-Jie,Ren ^[7] ; Hao,Fang ^[8] ; Jin-Peng,Sun ^[9]

作者单位： Key Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, School of Medicine, Shandong University, Jinan, Shandong 250012, China; Department of Physiology, School of Medicine, Shandong University, Jinan, Shandong 250012, China. ^[1] Key Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, School of Medicine, Shandong University, Jinan, Shandong 250012, China. ^[2] Key Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, School of Medicine, Shandong University, Jinan, Shandong 250012, China; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology of Natural Products (MOE), School of Pharmacy, Shandong University, Jinan, Shandong 250012, China. ^[3] Department of Medicinal Chemistry, Key Laboratory of Chemical Biology of Natural Products (MOE), School of Pharmacy, Shandong University, Jinan, Shandong 250012, China. ^[4] Department of Physiology, School of Medicine, Shandong University, Jinan, Shandong 250012, China. ^[5] Department of Biochemistry, School of Medicine, Duke University, Durham, NC 27705, USA. ^[6] Key Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, School of Medicine, Shandong University, Jinan, Shandong 250012, China. Electronic address: rengj@sdu.edu.cn. ^[7] Department of Medicinal Chemistry, Key Laboratory of Chemical Biology of Natural Products (MOE), School of Pharmacy, Shandong University, Jinan, Shandong 250012, China. Electronic address: haofangcn@sdu.edu.cn. ^[8] Key Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, School of Medicine, Shandong University, Jinan, Shandong 250012, China. Electronic address: sunjinpeng@sdu.edu.cn. ^[9]

关键词 Covalent inhibitor Irreversible PTP Probe STEP

主题词酶抑制剂(Enzyme Inhibitors);人类(Humans);咪唑类(Imidazoles);动力学(Kinetics);磷酰化(Phosphorylation);蛋白质酪氨酸磷酸酶类(Protein Tyrosine Phosphatases);噻唑类(Thiazoles)

DOI 10.1016/j.bmcl.2016.08.024

PMID 27554446

发布时间 2017-11-22

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交