Determinants of host susceptibility to murine respiratory syncytial virus (RSV) disease identify a role for the innate immunity scavenger receptor MARCO gene in human infants.

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第一作者： Monica,High

第一单位： Immunity, Inflammation, and Diseases Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.

作者： Monica,High ^[1] ; Hye-Youn,Cho ^[1] ; Jacqui,Marzec ^[1] ; Tim,Wiltshire ^[2] ; Kirsten C,Verhein ^[1] ; Mauricio T,Caballero ^[3] ; Patricio L,Acosta ^[4] ; Jonathan,Ciencewicki ^[1] ; Zackary R,McCaw ^[1] ; Lester,Kobzik ^[5] ; Laura,Miller-DeGraff ^[1] ; Wes,Gladwell ^[1] ; David B,Peden ^[6] ; M Elina,Serra ^[3] ; Min,Shi ^[7] ; Clarice,Weinberg ^[7] ; Oscar,Suzuki ^[2] ; Xuting,Wang ^[8] ; Douglas A,Bell ^[8] ; Fernando P,Polack ^[9] ; Steven R,Kleeberger ^[10]

作者单位： Immunity, Inflammation, and Diseases Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. ^[1] Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA. ^[2] Fundación INFANT, Buenos Aires, Argentina. ^[3] Fundación INFANT, Buenos Aires, Argentina; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Buenos Aires, Argentina. ^[4] Department of Environmental Health, Harvard University School of Public Health, Boston, MA, USA. ^[5] Center for Environmental Medicine, Asthma and Lung Biology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. ^[6] Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. ^[7] Genome Integrity & Structural Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. ^[8] Fundación INFANT, Buenos Aires, Argentina; Department of Pediatrics, Vanderbilt University, Nashville, TN, USA. Electronic address: fernando.p.polack@vanderbilt.edu. ^[9] Immunity, Inflammation, and Diseases Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. Electronic address: kleeber1@niehs.nih.gov. ^[10]

关键词 Haplotype Infectious disease Innate immunity Lung Promoter SNP Single nucleotide polymorphism

主题词等位基因(Alleles);动物(Animals);病例对照研究(Case-Control Studies);疾病模型, 动物(Disease Models, Animal);疾病易感性(Disease Susceptibility);基因表达谱(Gene Expression Profiling);疾病遗传易感性(Genetic Predisposition to Disease);全基因组关联研究(Genome-Wide Association Study);基因型(Genotype);单倍型(Haplotypes);人类(Humans);免疫, 先天(Immunity, Innate);婴儿(Infant);婴儿, 新生(Infant, Newborn);男(雄)性(Male);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);表型(Phenotype);多态性, 单核苷酸(Polymorphism, Single Nucleotide);启动区, 遗传(Promoter Regions, Genetic);数量性状基因座位(Quantitative Trait Loci);受体, 免疫(Receptors, Immunologic);呼吸道合胞体病毒感染(Respiratory Syncytial Virus Infections);呼吸道合胞病毒(Respiratory Syncytial Viruses);序列缺失(Sequence Deletion);疾病严重程度指数(Severity of Illness Index)

DOI 10.1016/j.ebiom.2016.08.011

PMID 27554839

发布时间 2018-11-13

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2016年11卷

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Determinants of host susceptibility to murine respiratory syncytial virus (RSV) disease identify a role for the innate immunity scavenger receptor MARCO gene in human infants.

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Determinants of host susceptibility to murine respiratory syncytial virus (RSV) disease identify a role for the innate immunity scavenger receptor MARCO gene in human infants.

EBioMedicine

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EBioMedicine

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