Low-dose Actinomycin-D treatment re-establishes the tumoursuppressive function of P53 in RELA-positive ependymoma.-论文-万方医学网

作者： Theophilos,Tzaridis ^[1] ; Till,Milde ^[2] ; Kristian W,Pajtler ^[3] ; Sebastian,Bender ^[4] ; David T W,Jones ^[1] ; Simone,Müller ^[2] ; Andrea,Wittmann ^[4] ; Magdalena,Schlotter ^[1] ; Andreas E,Kulozik ^[1] ; Peter,Lichter ^[5] ; V,Peter Collins ^[1] ; Olaf,Witt ^[6] ; Marcel,Kool ^[2] ; Andrey,Korshunov ^[6] ; Stefan M,Pfister ^[7] ; Hendrik,Witt ^[2]

作者单位： Division of Pediatric Neurooncology (B062), German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. ^[1] Department of Pediatric Oncology, Hematology and Immunology, Children's Hospital, University of Heidelberg, Heidelberg, Germany. ^[2] Clinical Cooperation Unit Pediatric Oncology (G340), German Cancer Research Center (DKFZ), Heidelberg, Germany. ^[3] National Center for Tumor diseases (NCT), Clinical Trial Center, Heidelberg, Germany. ^[4] Department of Cardiology, Angiology and Pulmology, University of Heidelberg, Heidelberg, Germany. ^[5] Division of Molecular Genetics (B060), German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany. ^[6] Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge UK. ^[7] Clinical Cooperation Unit Neuropathology (G380), German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany. ^[8] Department of Neuropathology, Heidelberg University Hospital, Heidelberg, Germany. ^[9]

主题词动物(Animals);细胞凋亡(Apoptosis);细胞系, 肿瘤(Cell Line, Tumor);周期素依赖激酶抑制剂p21(Cyclin-Dependent Kinase Inhibitor p21);DNA突变分析(DNA Mutational Analysis);更生霉素(Dactinomycin);室管膜瘤(Ependymoma);基因表达谱(Gene Expression Profiling);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);人类(Humans);咪唑类(Imidazoles);免疫组织化学(Immunohistochemistry);髓母细胞瘤(Medulloblastoma);小鼠(Mice);神经元(Neurons);哌嗪类(Piperazines);蛋白质合成抑制药(Protein Synthesis Inhibitors);原癌基因蛋白质c-mdm2(Proto-Oncogene Proteins c-mdm2);干细胞(Stem Cells);转录因子RelA(Transcription Factor RelA);治疗结果(Treatment Outcome);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53)

DOI 10.18632/oncotarget.11452

PMID 27556362

发布时间 2018-11-13

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Low-dose Actinomycin-D treatment re-establishes the tumoursuppressive function of P53 in RELA-positive ependymoma.

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Low-dose Actinomycin-D treatment re-establishes the tumoursuppressive function of P53 in RELA-positive ependymoma.

Oncotarget

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Oncotarget

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