A coding variant in <i>FTO</i> confers susceptibility to thiopurine-induced leukopenia in East Asian patients with IBD.-论文-万方医学网

作者： Han Sang,Kim ^[1] ; Jae Hee,Cheon ^[2] ; Eun Suk,Jung ^[2] ; Joonhee,Park ^[3] ; Sowon,Aum ^[1] ; Soo Jung,Park ^[3] ; Sungho,Eun ^[1] ; Jinu,Lee ^[1] ; Ulrich,Rüther ^[3] ; Giles S H,Yeo ^[1] ; Marcella,Ma ^[4] ; Kyong Soo,Park ^[5] ; Takeo,Naito ^[6] ; Yoichi,Kakuta ^[6] ; Ji Hyun,Lee ^[7] ; Won Ho,Kim ^[8] ; Min Goo,Lee ^[8]

作者单位： Department of Pharmacology, Yonsei University College of Medicine, Seoul, Korea. ^[1] Brain Korea 21 Project for Medical Sciences, Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea. ^[2] Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea. ^[3] College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Inchon, Korea. ^[4] Institute for Animal Developmental and Molecular Biology, Heinrich Heine University, Universitätsstr. 1, Düsseldorf, Germany. ^[5] University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. ^[6] Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. ^[7] Division of Gastroenterology, Tohoku University Hospital, Miyagi, Japan. ^[8] Department of Clinical Pharmacology and Therapeutics, College of Medicine, Kyung Hee University, Seoul, Korea. ^[9]

主题词青少年(Adolescent);成年人(Adult);老年人(Aged);动物(Animals);硫唑嘌呤(Azathioprine);病例对照研究(Case-Control Studies);队列研究(Cohort Studies);女(雌)性(Female);遗传标记(Genetic Markers);全基因组关联研究(Genome-Wide Association Study);高通量核苷酸序列分析(High-Throughput Nucleotide Sequencing);人类(Humans);免疫抑制剂(Immunosuppressive Agents);炎性肠疾病(Inflammatory Bowel Diseases);白细胞减少(Leukopenia);男(雄)性(Male);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);中年人(Middle Aged);多态性, 单核苷酸(Polymorphism, Single Nucleotide);韩国(Republic of Korea);序列分析, DNA(Sequence Analysis, DNA);青年人(Young Adult)

DOI 10.1136/gutjnl-2016-311921

PMID 27558924

发布时间 2022-03-17

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A coding variant in <i>FTO</i> confers susceptibility to thiopurine-induced leukopenia in East Asian patients with IBD.

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A coding variant in <i>FTO</i> confers susceptibility to thiopurine-induced leukopenia in East Asian patients with IBD.

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