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A genome-wide association meta-analysis of diarrhoeal disease in young children identifies FUT2 locus and provides plausible biological pathways.

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第一作者: Mariona,Bustamante
第一单位: ISGlobal, Center for Research in Environmental Epidemiology (CREAL), Barcelona, Spain mariona.bustamante@isglobal.org.;Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.;Pompeu Fabra University (UPF), Barcelona, Spain.;CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.
作者单位: ISGlobal, Center for Research in Environmental Epidemiology (CREAL), Barcelona, Spain mariona.bustamante@isglobal.org.;Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.;Pompeu Fabra University (UPF), Barcelona, Spain.;CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain. [1] Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany. [2] ISGlobal, Barcelona Ctr. Int. Health Res. (CRESIB), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.;Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique. [3] ISGlobal, Center for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.;Pompeu Fabra University (UPF), Barcelona, Spain.;CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain. [4] The Generation R Study Group, Erasmus MC, Rotterdam, The Netherlands.;Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.;Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands. [5] MRC/University of Bristol Integrative Epidemiology Unit, University of Bristol, Bristol, UK.;School of Social and Community Medicine, University of Bristol, Bristol, UK. [6] COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. [7] Department of Obstetrics and Gynecology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. [8] Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. [9] Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.;Ludwig-Maximilians-University of Munich, Dr. von Hauner Children's Hospital, Division of Metabolic Diseases and Nutritional Medicine, Munich, Germany. [10] Department of Genetics and Bioinformatics, Area of Health Data and Digitalisation, Institute of Public Health, Oslo, Norway. [11] CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.;Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, València, Spain. [12] Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.;Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany. [13] Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.;Department of Pediatrics, Erasmus MC, Rotterdam, The Netherlands.;Leiden University College, The Hague, The Netherlands. [14] The Generation R Study Group, Erasmus MC, Rotterdam, The Netherlands.;Department of Pediatrics, Erasmus MC, Rotterdam, The Netherlands. [15] MRC/University of Bristol Integrative Epidemiology Unit, University of Bristol, Bristol, UK.;School of Social and Community Medicine, University of Bristol, Bristol, UK.;University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia. [16] Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.;Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.;Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. [17] Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.;Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.;Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.;Division of Endocrinology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. [18] Department of Obstetrics and Gynecology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.;Department of Genetics and Bioinformatics, Area of Health Data and Digitalisation, Institute of Public Health, Oslo, Norway. [19] Department of Pediatrics, Erasmus MC, Rotterdam, The Netherlands. [20] Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.;Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Inner City Clinic, University Hospital of Munich (LMU), Munich, Germany. [21] Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.;Pompeu Fabra University (UPF), Barcelona, Spain.;CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.;IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.;Experimental Genetics, Sidra Medical and Research Centre, Doha, Qatar. [22] ISGlobal, Center for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.;Pompeu Fabra University (UPF), Barcelona, Spain.;CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.;IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain. [23]
DOI 10.1093/hmg/ddw264
PMID 27559109
发布时间 2025-05-30
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