Structures of Ebola virus GP and sGP in complex with therapeutic antibodies.

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作者： Jesper,Pallesen ^[1] ; Charles D,Murin ^[1] ; Natalia,de Val ^[2] ; Christopher A,Cottrell ^[1] ; Kathryn M,Hastie ^[1] ; Hannah L,Turner ^[2] ; Marnie L,Fusco ^[1] ; Andrew I,Flyak ^[2] ; Larry,Zeitlin ^[3] ; James E,Crowe ^[4] ; Kristian G,Andersen ^[3] ; Erica Ollmann,Saphire ^[5] ; Andrew B,Ward ^[6]

作者单位： Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California 92037, USA. ^[1] Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92037, USA. ^[2] Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, Tennessee 37232, USA. ^[3] Mapp Biopharmaceutical, San Diego, California 92121, USA. ^[4] Department of Pediatrics, Vanderbilt University, Nashville, Tennessee 37232, USA. ^[5] Vanderbilt Vaccine Center, Vanderbilt University, Nashville, Tennessee 37232, USA. ^[6] Scripps Translational Institute, La Jolla, California 92122, USA. ^[7] The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA. ^[8]

主题词氨基酸序列(Amino Acid Sequence);抗体, 单克隆(Antibodies, Monoclonal);抗体生成(Antibody Formation);交叉反应(Cross Reactions);冷冻电子显微镜检查(Cryoelectron Microscopy);埃博拉病毒(Ebolavirus);表位(Epitopes);糖蛋白类(Glycoproteins);出血热, 埃博拉(Hemorrhagic Fever, Ebola);人类(Humans);膜糖蛋白类(Membrane Glycoproteins);模型, 结构(Models, Structural);突变(Mutation);蛋白质多聚化(Protein Multimerization);序列比对(Sequence Alignment);病毒蛋白质类(Viral Proteins)

DOI 10.1038/nmicrobiol.2016.128

PMID 27562261

发布时间 2019-01-13

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Nature microbiology

2016年1卷9期

16128页

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Structures of Ebola virus GP and sGP in complex with therapeutic antibodies.

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Structures of Ebola virus GP and sGP in complex with therapeutic antibodies.

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