Discovery of novel 5-hydroxy-4-pyridone-3-carboxy acids as potent inhibitors of influenza Cap-dependent endonuclease.

导出原文传递

翻译打印收藏纠错

第一作者： Masayoshi,Miyagawa

第一单位： Medicinal Chemistry Research Laboratory, Shionogi & Co., Ltd, 1-1, Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: masayoshi.miyagawa@shionogi.co.jp.

作者： Masayoshi,Miyagawa ^[1] ; Toshiyuki,Akiyama ^[2] ; Minako,Mikamiyama-Iwata ^[2] ; Kazunari,Hattori ^[2] ; Naoko,Kurihara ^[2] ; Yoshiyuki,Taoda ^[2] ; Chika,Takahashi-Kageyama ^[2] ; Noriyuki,Kurose ^[2] ; Hidenori,Mikamiyama ^[2] ; Naoyuki,Suzuki ^[2] ; Kenji,Takaya ^[2] ; Kenji,Tomita ^[2] ; Kenji,Matsuo ^[2] ; Kenji,Morimoto ^[3] ; Ryu,Yoshida ^[4] ; Takao,Shishido ^[4] ; Tomokazu,Yoshinaga ^[4] ; Akihiko,Sato ^[4] ; Makoto,Kawai ^[2]

作者单位： Medicinal Chemistry Research Laboratory, Shionogi & Co., Ltd, 1-1, Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: masayoshi.miyagawa@shionogi.co.jp. ^[1] Medicinal Chemistry Research Laboratory, Shionogi & Co., Ltd, 1-1, Futabacho, 3-chome, Toyonaka 561-0825, Japan. ^[2] Research Laboratory for Development, Shionogi & Co., Ltd, 1-1, Futabacho, 3-chome, Toyonaka 561-0825, Japan. ^[3] Drug Discovery & Disease Research Laboratory, Shionogi & Co., Ltd, 1-1, Futabacho, 3-chome, Toyonaka 561-0825, Japan. ^[4]

关键词 Anti-influenza drug Cap-dependent endonuclease Chelator Pyridone Virtual modeling