Neurological disease mutations of α3 Na<sup>+</sup>,K<sup>+</sup>-ATPase: Structural and functional perspectives and rescue of compromised function.

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作者： Rikke,Holm ^[1] ; Mads S,Toustrup-Jensen ^[2] ; Anja P,Einholm ^[3] ; Vivien R,Schack ^[4] ; Jens P,Andersen ^[5] ; Bente,Vilsen ^[6]

作者单位： Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark. Electronic address: rhj@biomed.au.dk. ^[1] Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark. Electronic address: mtj@biomed.au.dk. ^[2] Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark. Electronic address: ape@biomed.au.dk. ^[3] Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark. Electronic address: vs@biomed.au.dk. ^[4] Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark. Electronic address: jpa@biomed.au.dk. ^[5] Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark. Electronic address: bv@biomed.au.dk. ^[6]

关键词 Alternating hemiplegia of childhood (AHC)Na(+) site Na(+),K(+)-pump Protein structure Rapid-onset dystonia parkinsonism (RDP)Second-site mutation

主题词动物(Animals);人类(Humans);分子动力学模拟(Molecular Dynamics Simulation);突变(Mutation);神经变性疾病(Neurodegenerative Diseases);表型(Phenotype);钠钾交换ATP酶(Sodium-Potassium-Exchanging ATPase)

DOI 10.1016/j.bbabio.2016.08.009

PMID 27577505

发布时间 2022-04-08

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