Francisella tularensis Live Vaccine Strain deficient in capB and overexpressing the fusion protein of IglA, IglB, and IglC from the bfr promoter induces improved protection against F. tularensis respiratory challenge.-论文-万方医学网

第一作者： Qingmei,Jia

第一单位： Division of Infectious Diseases, Department of Medicine, 37-121 Center for Health Sciences, School of Medicine, University of California - Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095-1688, United States. Electronic address: QJia@mednet.ucla.edu.

作者： Qingmei,Jia ^[1] ; Richard,Bowen ^[2] ; Bai-Yu,Lee ^[3] ; Barbara Jane,Dillon ^[4] ; Saša,Masleša-Galić ^[5] ; Marcus A,Horwitz ^[6]

作者单位： Division of Infectious Diseases, Department of Medicine, 37-121 Center for Health Sciences, School of Medicine, University of California - Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095-1688, United States. Electronic address: QJia@mednet.ucla.edu. ^[1] Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, United States. Electronic address: rbowen@rams.colostate.edu. ^[2] Division of Infectious Diseases, Department of Medicine, 37-121 Center for Health Sciences, School of Medicine, University of California - Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095-1688, United States. Electronic address: BaLee@mednet.ucla.edu. ^[3] Division of Infectious Diseases, Department of Medicine, 37-121 Center for Health Sciences, School of Medicine, University of California - Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095-1688, United States. Electronic address: BDillon@mednet.ucla.edu. ^[4] Division of Infectious Diseases, Department of Medicine, 37-121 Center for Health Sciences, School of Medicine, University of California - Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095-1688, United States. Electronic address: SGalic@mednet.ucla.edu. ^[5] Division of Infectious Diseases, Department of Medicine, 37-121 Center for Health Sciences, School of Medicine, University of California - Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095-1688, United States. Electronic address: MHorwitz@mednet.ucla.edu. ^[6]

主题词动物(Animals);细菌荚膜(Bacterial Capsules);细菌蛋白质类(Bacterial Proteins);细菌菌苗(Bacterial Vaccines);细胞色素b组(Cytochrome b Group);女(雌)性(Female);铁蛋白质类(Ferritins);土拉热弗朗西丝菌(Francisella tularensis);基因组岛(Genomic Islands);人类(Humans);干扰素γ(Interferon-gamma);白细胞介素17(Interleukin-17);巨噬细胞(Macrophages);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);暴露后预防(Post-Exposure Prophylaxis);启动区, 遗传(Promoter Regions, Genetic);重组融合蛋白质类(Recombinant Fusion Proteins);序列缺失(Sequence Deletion);土拉菌病(Tularemia);疫苗, 减毒(Vaccines, Attenuated);疫苗, 合成(Vaccines, Synthetic)

DOI 10.1016/j.vaccine.2016.08.041

PMID 27577555

发布时间 2020-12-09

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Francisella tularensis Live Vaccine Strain deficient in capB and overexpressing the fusion protein of IglA, IglB, and IglC from the bfr promoter induces improved protection against F. tularensis respiratory challenge.

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Francisella tularensis Live Vaccine Strain deficient in capB and overexpressing the fusion protein of IglA, IglB, and IglC from the bfr promoter induces improved protection against F. tularensis respiratory challenge.

Vaccine

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Vaccine

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