ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival.

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第一作者： Wenbin,Zhong

第一单位： Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Department of Biotechnology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.

作者： Wenbin,Zhong ^[1] ; Qing,Yi ^[2] ; Bing,Xu ^[3] ; Shiqian,Li ^[1] ; Tong,Wang ^[1] ; Fupei,Liu ^[1] ; Biying,Zhu ^[1] ; Peter R,Hoffmann ^[4] ; Guangju,Ji ^[5] ; Pingsheng,Lei ^[6] ; Guoping,Li ^[7] ; Jiwei,Li ^[1] ; Jian,Li ^[7] ; Vesa M,Olkkonen ^[8] ; Daoguang,Yan ^[1]

作者单位： Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Department of Biotechnology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China. ^[1] Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA. ^[2] Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. ^[3] Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96813, USA. ^[4] National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. ^[5] State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Chinese Academy of Medical Sciences, Beijing 100050, China. ^[6] The Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology &Beijing Institute of Geriatrics, Ministry of Health, Beijing 100730, China. ^[7] Minerva Foundation Institute for Medical Research, Biomedicum 2U, Helsinki FI-00290, Finland. ^[8]

主题词腺苷三磷酸(Adenosine Triphosphate);动物(Animals);钙(Calcium);钙信号(Calcium Signaling);细胞系, 肿瘤(Cell Line, Tumor);细胞存活(Cell Survival);内质网(Endoplasmic Reticulum);女(雌)性(Female);人类(Humans);Jurkat细胞(Jurkat Cells);小鼠(Mice);小鼠, 近交NOD(Mice, Inbred NOD);小鼠, SCID(Mice, SCID);线粒体(Mitochondria);氧化磷酸化(Oxidative Phosphorylation);磷脂酶Cβ(Phospholipase C beta);前体T细胞淋巴母细胞白血病淋巴瘤(Precursor T-Cell Lymphoblastic Leukemia-Lymphoma);受体, 类固醇(Receptors, Steroid);T淋巴细胞(T-Lymphocytes)

DOI 10.1038/ncomms12702

PMID 27581363

发布时间 2025-01-03

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ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival.

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ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival.

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