Acquisition of an oncogenic fusion protein serves as an initial driving mutation by inducing aneuploidy and overriding proliferative defects.-论文-万方医学网

第一作者： Jacob M,Loupe

第一单位： Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA, USA.;Center for Human Genetic Research, Massachusetts General Hospital, Richard B. Simches Research Center, Boston, MA, USA.

作者： Jacob M,Loupe ^[1] ; Patrick J,Miller ^[2] ; Benjamin P,Bonner ^[3] ; Elaine C,Maggi ^[3] ; Jyothi,Vijayaraghavan ^[3] ; Jovanny,Zabaleta ^[4] ; Christopher M,Taylor ^[5] ; Fern,Tsien ^[3] ; Judy S,Crabtree ^[3] ; Andrew D,Hollenbach ^[3]

作者单位： Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA, USA.;Center for Human Genetic Research, Massachusetts General Hospital, Richard B. Simches Research Center, Boston, MA, USA. ^[1] Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA, USA.;Tulane University, New Orleans, LA, USA. ^[2] Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA, USA. ^[3] Department of Pediatrics and Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA, USA. ^[4] Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA, USA. ^[5]

医学主题词非整倍性(Aneuploidy);动物(Animals);细胞周期(Cell Cycle);细胞增殖(Cell Proliferation);细胞转化, 肿瘤(Cell Transformation, Neoplastic);染色体畸变(Chromosome Aberrations);疾病恶化(Disease Progression);基因表达谱(Gene Expression Profiling);人类(Humans);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);微RNAs(MicroRNAs);有丝分裂(Mitosis);肌肉发育(Muscle Development);突变(Mutation);成肌细胞(Myoblasts);癌基因蛋白质类, 融合(Oncogene Proteins, Fusion);磷酰化(Phosphorylation);蛋白质加工, 转译后(Protein Processing, Post-Translational);RNA, 信使(RNA, Messenger);横纹肌肉瘤, 腺泡状(Rhabdomyosarcoma, Alveolar);易位, 遗传(Translocation, Genetic)

DOI 10.18632/oncotarget.11716

PMID 27588498

发布时间 2018-11-13

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Acquisition of an oncogenic fusion protein serves as an initial driving mutation by inducing aneuploidy and overriding proliferative defects.

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Acquisition of an oncogenic fusion protein serves as an initial driving mutation by inducing aneuploidy and overriding proliferative defects.

Oncotarget

相似文献

同项目论文

Oncotarget

相关期刊

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