Phosphocreatine protects endothelial cells from Methylglyoxal induced oxidative stress and apoptosis via the regulation of PI3K/Akt/eNOS and NF-κB pathway.
作者:
主题词
抗氧化剂(Antioxidants);细胞凋亡(Apoptosis);凋亡调节蛋白质类(Apoptosis Regulatory Proteins);细胞, 培养的(Cells, Cultured);细胞保护(Cytoprotection);剂量效应关系, 药物(Dose-Response Relationship, Drug);人类(Humans);膜电位, 线粒体(Membrane Potential, Mitochondrial);线粒体(Mitochondria);NF-κB(NF-kappa B);一氧化氮合酶Ⅲ型(Nitric Oxide Synthase Type III);氧化性应激(Oxidative Stress);磷酸肌醇3-激酶(Phosphatidylinositol 3-Kinase);磷酸肌酸(Phosphocreatine);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);丙酮醛(Pyruvaldehyde);活性氧(Reactive Oxygen Species);信号传导(Signal Transduction)
DOI
10.1016/j.vph.2016.08.012
PMID
27590258
发布时间
2018-01-31
- 浏览2
Vascular pharmacology
26-35页
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