The flexibility of a generic LC-MS/MS method for the quantitative analysis of therapeutic proteins based on human immunoglobulin G and related constructs in animal studies.

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作者： Christian,Lanshoeft ^[1] ; Thierry,Wolf ^[2] ; Markus,Walles ^[2] ; Samuel,Barteau ^[2] ; Franck,Picard ^[2] ; Olivier,Kretz ^[2] ; Sarah,Cianférani ^[3] ; Olivier,Heudi ^[4]

作者单位： Novartis Institutes for Biomedical Research, Drug Metabolism and Pharmacokinetics, Fabrikstrasse 14 - Novartis Campus, 4056, Basel, Switzerland; Laboratoire de Spectrométrie de Masse BioOrganique, Institut Pluridisciplinaire Hubert Curien, CNRS-Université de Strasbourg, UMR 7178, 25 rue Becquerel, 67087, Strasbourg, France. ^[1] Novartis Institutes for Biomedical Research, Drug Metabolism and Pharmacokinetics, Fabrikstrasse 14 - Novartis Campus, 4056, Basel, Switzerland. ^[2] Laboratoire de Spectrométrie de Masse BioOrganique, Institut Pluridisciplinaire Hubert Curien, CNRS-Université de Strasbourg, UMR 7178, 25 rue Becquerel, 67087, Strasbourg, France. ^[3] Novartis Institutes for Biomedical Research, Drug Metabolism and Pharmacokinetics, Fabrikstrasse 14 - Novartis Campus, 4056, Basel, Switzerland. Electronic address: heudio@hotmail.fr. ^[4]

关键词 Generic peptide Liquid chromatography tandem mass spectrometry Pellet digestion Pre-clinical species Therapeutic proteins