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CSF profiling of the human brain enriched proteome reveals associations of neuromodulin and neurogranin to Alzheimer's disease.

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第一作者： Julia,Remnestål

第一单位： Affinity Proteomics, SciLifeLab, KTH-Royal Institute of Technology, Stockholm, Sweden.

作者： Julia,Remnestål ^[1] ; David,Just ^[1] ; Nicholas,Mitsios ^[2] ; Claudia,Fredolini ^[1] ; Jan,Mulder ^[2] ; Jochen M,Schwenk ^[1] ; Mathias,Uhlén ^[1] ; Kim,Kultima ^[3] ; Martin,Ingelsson ^[4] ; Lena,Kilander ^[4] ; Lars,Lannfelt ^[4] ; Per,Svenningsson ^[5] ; Bengt,Nellgård ^[6] ; Henrik,Zetterberg ^[7] ; Kaj,Blennow ^[8] ; Peter,Nilsson ^[1] ; Anna,Häggmark-Månberg ^[1]

作者单位： Affinity Proteomics, SciLifeLab, KTH-Royal Institute of Technology, Stockholm, Sweden. ^[1] SciLifeLab, Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden. ^[2] Department of Medical Sciences, Cancer Pharmacology and Computational Medicine, Uppsala University, Uppsala, Sweden. ^[3] Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden. ^[4] Translational Neuropharmacology, Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden. ^[5] Department of Anaesthesiology and Intensive Care, Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden. ^[6] Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.;Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.;Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, UK. ^[7] Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.;Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden. ^[8]

关键词 Alzheimer's disease Cerebrospinal fluid Neurogranin Neuromodulin Neuroproteomics