HIV-1 gp120 Glycoprotein Interacting with Dendritic Cell-specific Intercellular Adhesion Molecule 3-grabbing Non-integrin (DC-SIGN) Down-Regulates Tight Junction Proteins to Disrupt the Blood Retinal Barrier and Increase Its Permeability.

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第一作者： Yi-Wen,Qian

第一单位： From the Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai 200011, China.

作者： Yi-Wen,Qian ^[1] ; Chuan,Li ^[1] ; Ai-Ping,Jiang ^[2] ; Shengfang,Ge ^[1] ; Ping,Gu ^[1] ; Xianqun,Fan ^[1] ; Tai-Sheng,Li ^[3] ; Xia,Jin ^[2] ; Jian-Hua,Wang ^[4] ; Zhi-Liang,Wang ^[5]

作者单位： From the Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai 200011, China. ^[1] the Chinese Academy of Sciences Key Laboratory of Molecular Virology and Immunology and. ^[2] the Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China. ^[3] Viral Disease and Vaccine Translational Research Unit and Vaccine Center, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China, and. ^[4] the Chinese Academy of Sciences Key Laboratory of Molecular Virology and Immunology and jh_wang@sibs.ac.cn. ^[5] From the Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai 200011, China, ophwzl@163.com. ^[6]

关键词 DC-SIGN HIV HIV-1 blood-retinal barrier glycoprotein matrix metalloproteinase (MMP)retina tight junction tight junction protein