Plasminogen activator inhibitor type 1 in platelets induces thrombogenicity by increasing thrombolysis resistance under shear stress in an in-vitro flow chamber model.

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作者： Kazuya,Hosokawa ^[1] ; Tomoko,Ohnishi-Wada ^[1] ; Hisayo,Sameshima-Kaneko ^[1] ; Tomoka,Nagasato ^[2] ; Naoki,Miura ^[3] ; Kiyoshi,Kikuchi ^[4] ; Takehiko,Koide ^[5] ; Ikuro,Maruyama ^[5] ; Tetsumei,Urano ^[6]

作者单位： Research Institute, Fujimori Kogyo Co., Ltd., 1-10-1, Sachiura, Kanazawa-ku, Yokohama, Kanagawa 236-0003, Japan. ^[1] Research Institute, Fujimori Kogyo Co., Ltd., 1-10-1, Sachiura, Kanazawa-ku, Yokohama, Kanagawa 236-0003, Japan; Department of System Biology in Thromboregulation, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima 890-8544, Japan. ^[2] Joint Faculty of Veterinary Medicine, Kagoshima University, 1-21-24, Koorimoto, Kagoshima 890-0065, Japan. ^[3] Department of Physiology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka 830-0011, Japan; Department of Neurosurgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka 830-0011, Japan. ^[4] Department of System Biology in Thromboregulation, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima 890-8544, Japan. ^[5] Department of Medical Physiology, Hamamatsu University School of Medicine, 1-20-1, Handa-yama, Higashi-ku, Hamamatsu, Shizuoka 431-3192, Japan. Electronic address: uranot@hama-med.ac.jp. ^[6]

关键词 Flow chamber Platelets Thrombolysis Tissue plasminogen activator