Approaches for the estimation of timescales in nonlinear dynamical systems: Timescale separation in enzyme kinetics as a case study.

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作者： S K,Shoffner ^[1] ; Santiago,Schnell ^[2]

作者单位： Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address: suzshoff@umich.edu. ^[1] Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Computational Medicine & Bioinformatics, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Brehm Center for Diabetes Research, University of Michigan Medical School, Ann Arbor, MI 48105, USA. Electronic address: schnells@umich.edu. ^[2]

关键词 Inverse rates Minimum simplification Pairwise balances Quasi-steady-state approximation Scaling and simplification Timescale separation

主题词酶类(Enzymes);模型, 生物学(Models, Biological);非线性动力学(Nonlinear Dynamics)

DOI 10.1016/j.mbs.2016.09.001

PMID 27613486

发布时间 2018-07-19

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