Overcome tumor heterogeneity-imposed therapeutic barriers through convergent genomic biomarker discovery: A braided cancer river model of kidney cancer.

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第一作者： James J,Hsieh

第一单位： Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, United States. Electronic address: hsiehj@mskcc.org.

作者： James J,Hsieh ^[1] ; Brandon J,Manley ^[2] ; Nabeela,Khan ^[3] ; JianJiong,Gao ^[4] ; Maria I,Carlo ^[5] ; Emily H,Cheng ^[6]

作者单位： Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, United States. Electronic address: hsiehj@mskcc.org. ^[1] Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, United States. ^[2] Department of Medicine, State University of New York Downstate Medical Center, Brooklyn, NY11203, United States. ^[3] Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, United States. ^[4] Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, United States. ^[5] Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, United States; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, United States. ^[6]

关键词 Braided kidney cancer river model Branched/divergent evolution Genomic predictive biomarker Intermetastases heterogeneity (IMH)Intratumor heterogeneity (ITH)Parallel/convergent gene/pathway/function/phenotype evolution Precision medicine Targeted therapy

主题词动物(Animals);生物进化(Biological Evolution);遗传异质性(Genetic Heterogeneity);基因组学(Genomics);人类(Humans);肾肿瘤(Kidney Neoplasms);模型, 生物学(Models, Biological)

DOI 10.1016/j.semcdb.2016.09.002

PMID 27615548

发布时间 2024-06-03

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