TDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons.

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作者： Benjamin M,Schwenk ^[1] ; Hannelore,Hartmann ^[2] ; Alperen,Serdaroglu ^[1] ; Martin H,Schludi ^[1] ; Daniel,Hornburg ^[3] ; Felix,Meissner ^[1] ; Denise,Orozco ^[2] ; Alessio,Colombo ^[4] ; Sabina,Tahirovic ^[4] ; Meike,Michaelsen ^[1] ; Franziska,Schreiber ^[1] ; Simone,Haupt ^[1] ; Michael,Peitz ^[1] ; Oliver,Brüstle ^[1] ; Clemens,Küpper ^[5] ; Thomas,Klopstock ^[6] ; Markus,Otto ^[7] ; Albert C,Ludolph ^[6] ; Thomas,Arzberger ^[2] ; Peer-Hendrik,Kuhn ^[8] ; Dieter,Edbauer ^[1]

作者单位： German Center for Neurodegenerative Diseases (DZNE), Munich, Germany. ^[1] Munich Cluster of Systems Neurology (SyNergy), Munich, Germany. ^[2] Institute for Advanced Study Technische Universität München, München, Germany. ^[3] Max Planck Institute of Biochemistry, Martinsried, Germany. ^[4] LIFE & BRAIN GmbH, Bonn, Germany. ^[5] Institute of Reconstructive Neurobiology University of Bonn, Bonn, Germany. ^[6] German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany. ^[7] Department of Neurology, Friedrich-Baur-Institute LMU Munich, Munich, Germany. ^[8] Department of Neurology, University of Ulm, Ulm, Germany. ^[9] Center for Neuropathology and Prion Research, LMU Munich, Munich, Germany. ^[10] Department of Psychiatry and Psychotherapy, LMU Munich, Munich, Germany. ^[11] Institut für Allgemeine Pathologie Klinikum rechts der Isar der Technischen Universität München, München, Germany. ^[12] German Center for Neurodegenerative Diseases (DZNE), Munich, Germany dieter.edbauer@dzne.de. ^[13] Institute for Metabolic Biochemistry LMU Munich, Munich, Germany. ^[14]

关键词 ALS ErbB4 FTLD TDP‐43 recycling endosomes