首页> The EMBO journal> TDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons.

TDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons.

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第一作者： Benjamin M,Schwenk

第一单位： German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.;Munich Cluster of Systems Neurology (SyNergy), Munich, Germany.

作者： Benjamin M,Schwenk ^[1] ; Hannelore,Hartmann ^[2] ; Alperen,Serdaroglu ^[3] ; Martin H,Schludi ^[1] ; Daniel,Hornburg ^[4] ; Felix,Meissner ^[4] ; Denise,Orozco ^[2] ; Alessio,Colombo ^[2] ; Sabina,Tahirovic ^[2] ; Meike,Michaelsen ^[2] ; Franziska,Schreiber ^[2] ; Simone,Haupt ^[5] ; Michael,Peitz ^[6] ; Oliver,Brüstle ^[7] ; Clemens,Küpper ^[8] ; Thomas,Klopstock ^[9] ; Markus,Otto ^[10] ; Albert C,Ludolph ^[10] ; Thomas,Arzberger ^[11] ; Peer-Hendrik,Kuhn ^[12] ; Dieter,Edbauer ^[13]

作者单位： German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.;Munich Cluster of Systems Neurology (SyNergy), Munich, Germany. ^[1] German Center for Neurodegenerative Diseases (DZNE), Munich, Germany. ^[2] German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.;Institute for Advanced Study Technische Universität München, München, Germany. ^[3] Max Planck Institute of Biochemistry, Martinsried, Germany. ^[4] LIFE & BRAIN GmbH, Bonn, Germany. ^[5] Institute of Reconstructive Neurobiology University of Bonn, Bonn, Germany.;German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany. ^[6] Institute of Reconstructive Neurobiology University of Bonn, Bonn, Germany. ^[7] Munich Cluster of Systems Neurology (SyNergy), Munich, Germany.;Department of Neurology, Friedrich-Baur-Institute LMU Munich, Munich, Germany. ^[8] German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.;Munich Cluster of Systems Neurology (SyNergy), Munich, Germany.;Department of Neurology, Friedrich-Baur-Institute LMU Munich, Munich, Germany. ^[9] Department of Neurology, University of Ulm, Ulm, Germany. ^[10] German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.;Center for Neuropathology and Prion Research, LMU Munich, Munich, Germany.;Department of Psychiatry and Psychotherapy, LMU Munich, Munich, Germany. ^[11] German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.;Institute for Advanced Study Technische Universität München, München, Germany.;Institut für Allgemeine Pathologie Klinikum rechts der Isar der Technischen Universität München, München, Germany. ^[12] German Center for Neurodegenerative Diseases (DZNE), Munich, Germany dieter.edbauer@dzne.de.;Munich Cluster of Systems Neurology (SyNergy), Munich, Germany.;Institute for Metabolic Biochemistry LMU Munich, Munich, Germany. ^[13]

关键词 ALS ErbB4 FTLD TDP‐43 recycling endosomes