Ionic immune suppression within the tumour microenvironment limits T cell effector function.-论文-万方医学网

作者： Robert,Eil ^[1] ; Suman K,Vodnala ^[1] ; David,Clever ^[1] ; Christopher A,Klebanoff ^[1] ; Madhusudhanan,Sukumar ^[2] ; Jenny H,Pan ^[1] ; Douglas C,Palmer ^[1] ; Alena,Gros ^[1] ; Tori N,Yamamoto ^[1] ; Shashank J,Patel ^[1] ; Geoffrey C,Guittard ^[1] ; Zhiya,Yu ^[1] ; Valentina,Carbonaro ^[1] ; Klaus,Okkenhaug ^[3] ; David S,Schrump ^[3] ; W Marston,Linehan ^[1] ; Rahul,Roychoudhuri ^[1] ; Nicholas P,Restifo ^[3]

作者单位： National Cancer Institute, National Institutes of Health (NIH), Bethesda, Maryland 20892, USA. ^[1] Center for Cell Engineering and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA. ^[2] Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge CB22 3AT, UK. ^[3]

主题词动物(Animals);阳离子, 一价(Cations, Monovalent);人类(Humans);免疫耐受(Immune Tolerance);免疫疗法(Immunotherapy);Kv1.3钾通道(Kv1.3 Potassium Channel);男(雄)性(Male);黑色素瘤(Melanoma);膜电位(Membrane Potentials);小鼠(Mice);坏死(Necrosis);钾(Potassium);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);受体, 抗原, T细胞(Receptors, Antigen, T-Cell);信号传导(Signal Transduction);存活率分析(Survival Analysis);T淋巴细胞(T-Lymphocytes);TOR丝氨酸-苏氨酸激酶(TOR Serine-Threonine Kinases);肿瘤逃逸(Tumor Escape);肿瘤微环境(Tumor Microenvironment)

DOI 10.1038/nature19364

PMID 27626381

发布时间 2024-06-10

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Ionic immune suppression within the tumour microenvironment limits T cell effector function.

Nature

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Ionic immune suppression within the tumour microenvironment limits T cell effector function.

Nature

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Nature

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