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Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling.

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第一作者： Meike,Hohwieler

第一单位： Department of Internal Medicine I, University Medical Center Ulm, Ulm, Germany.

作者： Meike,Hohwieler ^[1] ; Anett,Illing ^[1] ; Patrick C,Hermann ^[1] ; Tobias,Mayer ^[1] ; Marianne,Stockmann ^[1] ; Lukas,Perkhofer ^[1] ; Tim,Eiseler ^[1] ; Justin S,Antony ^[2] ; Martin,Müller ^[1] ; Susanne,Renz ^[1] ; Chao-Chung,Kuo ^[3] ; Qiong,Lin ^[4] ; Matthias,Sendler ^[5] ; Markus,Breunig ^[1] ; Susanne M,Kleiderman ^[1] ; André,Lechel ^[1] ; Martin,Zenker ^[6] ; Michael,Leichsenring ^[7] ; Jonas,Rosendahl ^[8] ; Martin,Zenke ^[4] ; Bruno,Sainz ^[9] ; Julia,Mayerle ^[5] ; Ivan G,Costa ^[3] ; Thomas,Seufferlein ^[1] ; Michael,Kormann ^[2] ; Martin,Wagner ^[1] ; Stefan,Liebau ^[10] ; Alexander,Kleger ^[1]

作者单位： Department of Internal Medicine I, University Medical Center Ulm, Ulm, Germany. ^[1] Department of Pediatrics I, Pediatric Infectiology and Immunology, Translational Genomics and Gene Therapy in Pediatrics, University of Tuebingen, Tuebingen, Germany. ^[2] Medical Faculty, IZKF Computational Biology Research Group, RWTH Aachen University, Aachen, Germany. ^[3] Medical Faculty, Department of Cell Biology, Institute for Biomedical Engineering, RWTH Aachen University, Aachen, Germany. ^[4] Department of Medicine A, University Medicine, Ernst-Moritz-Arndt-University, Greifswald, Germany. ^[5] Institute of Human Genetics, University Hospital, Magdeburg, Germany. ^[6] Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany. ^[7] Department of Internal Medicine I, Division of Medicine, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany. ^[8] Department of Biochemistry, Universidad Autónoma de Madrid, Instituto de Investigaciones Biomédicas "Alberto Sols" CSIC-UAM, Madrid, Spain. ^[9] Institute of Neuroanatomy, Eberhard Karls University Tuebingen, Tuebingen, Germany. ^[10]

关键词 CYSTIC FIBROSIS PANCREAS STEM CELLS