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CD28/CTLA-4/ICOS haplotypes confers susceptibility to Graves' disease and modulates clinical phenotype of disease.

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第一作者： Edyta,Pawlak-Adamska

第一单位： Department of Experimental Therapy, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, R. Weigl 12, Wroclaw, 53-114, Poland. epawlak@iitd.pan.wroc.pl.

作者： Edyta,Pawlak-Adamska ^[1] ; Irena,Frydecka ^[2] ; Marek,Bolanowski ^[3] ; Anna,Tomkiewicz ^[2] ; Anna,Jonkisz ^[4] ; Lidia,Karabon ^[2] ; Anna,Partyka ^[2] ; Oskar,Nowak ^[5] ; Marek,Szalinski ^[6] ; Jacek,Daroszewski ^[3]

作者单位： Department of Experimental Therapy, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, R. Weigl 12, Wroclaw, 53-114, Poland. epawlak@iitd.pan.wroc.pl. ^[1] Department of Experimental Therapy, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, R. Weigl 12, Wroclaw, 53-114, Poland. ^[2] Department of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University, L. Pasteur 4, Wroclaw, 50-367, Poland. ^[3] Department of Forensic Medicine, Wroclaw Medical University, M. Curie-Sklodowska 52, Wroclaw, 50-369, Poland. ^[4] Department of Human Evolutionary Biology, Institute of Anthropology, Adam Mickiewicz University, Umultowska 89, Poznan, 61-614, Poland. ^[5] Department of Ophthalmology, Wroclaw Medical University, Borowska 213, Wroclaw, 50-556, Poland. ^[6]

关键词 CD28/CTLA-4/ICOS Gene polymorphism Graves’ disease Graves’ orbitopathy Haplotype