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首页> Journal of pharmaceutical sciences> Preparation and Physicochemical Characterization of an Inclusion Complex Between Dimethylated β-Cyclodextrin and a Drug Lead From a New Class of Orally Active Antimalarial 3,5-Diaryl-2-Aminopyridines.

Preparation and Physicochemical Characterization of an Inclusion Complex Between Dimethylated β-Cyclodextrin and a Drug Lead From a New Class of Orally Active Antimalarial 3,5-Diaryl-2-Aminopyridines.

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作者： Laurelle M,Joseph ^[1] ; Kelly,Chibale ^[2] ; Mino R,Caira ^[3]

作者单位： Department of Chemistry, Centre for Supramolecular Chemistry Research, University of Cape Town, Rondebosch, South Africa. ^[1] Department of Chemistry, South African Medical Research Council Drug Discovery and Development Research Unit, University of Cape Town, Rondebosch, South Africa; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch, South Africa. ^[2] Department of Chemistry, Centre for Supramolecular Chemistry Research, University of Cape Town, Rondebosch, South Africa. Electronic address: mino.caira@uct.ac.za. ^[3]

关键词 X-ray diffractometry complexation crystal structure crystallization cyclodextrins hydrates/solvates oral drug delivery physical characterization solubility thermal analysis

主题词投药, 口服(Administration, Oral);氨基吡啶类(Aminopyridines);动物(Animals);抗疟药(Antimalarials);化学现象(Chemical Phenomena);化学, 药物(Chemistry, Pharmaceutical);环糊精类(Cyclodextrins);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);X线衍射(X-Ray Diffraction);β环糊精类(beta-Cyclodextrins)

DOI 10.1016/j.xphs.2016.07.030

PMID 27640751

发布时间 2018-04-04

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Journal of pharmaceutical sciences

Journal of pharmaceutical sciences

2016年105卷11期

3344-3350页

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