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Free fatty acid receptor 1 (GPR40) agonists containing spirocyclic periphery inspired by LY2881835.

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第一作者： Mikhail,Krasavin

第一单位： Saint Petersburg State University, Saint Petersburg 199034, Russian Federation. Electronic address: m.krasavin@spbu.ru.

作者： Mikhail,Krasavin ^[1] ; Alexey,Lukin ^[2] ; Daria,Bagnyukova ^[2] ; Nikolay,Zhurilo ^[2] ; Ihor,Zahanich ^[3] ; Sergey,Zozulya ^[4] ; Jouni,Ihalainen ^[5] ; Markus M,Forsberg ^[5] ; Marko,Lehtonen ^[5] ; Jarkko,Rautio ^[5] ; Daniel,Moore ^[6] ; Irina G,Tikhonova ^[6]

作者单位： Saint Petersburg State University, Saint Petersburg 199034, Russian Federation. Electronic address: m.krasavin@spbu.ru. ^[1] Lomonosov Institute of Fine Chemical Technologies, Moscow Technological University, 86 Vernadskogo Prospekt, Moscow 117571, Russian Federation. ^[2] Enamine Ltd, 78 Chervonotkatska, Kyiv 02094, Ukraine. ^[3] Enamine Ltd, 78 Chervonotkatska, Kyiv 02094, Ukraine; Taras Shevchenko National University, 62 Volodymyrska, Kyiv 01033, Ukraine. ^[4] School of Pharmacy, University of Eastern Finland, 70211 Kuopio, Finland. ^[5] Molecular Therapeutics, School of Pharmacy, Medical Biology Centre, Queen's University Belfast, Belfast BT9 7BL, Northern Ireland, UK. ^[6]

关键词 FFA1 agonists Free fatty acid receptor 1 GPCR GPR40 Metabolic stability Prins reaction Spirocyclic motifs Type 2 diabetes mellitus

医学主题词剂量效应关系, 药物(Dose-Response Relationship, Drug);人类(Humans);分子结构(Molecular Structure);哌啶类(Piperidines);受体, G-蛋白偶联(Receptors, G-Protein-Coupled);螺环化合物(Spiro Compounds);构效关系(Structure-Activity Relationship)

DOI 10.1016/j.bmc.2016.09.004

PMID 27647366

发布时间 2017-12-07

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