A new Suzuki synthesis of triphenylethylenes that inhibit aromatase and bind to estrogen receptors α and β.

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作者： Li-Ming,Zhao ^[1] ; Hai-Shan,Jin ^[1] ; Jinzhong,Liu ^[2] ; Todd C,Skaar ^[2] ; Joseph,Ipe ^[2] ; Wei,Lv ^[3] ; David A,Flockhart ^[2] ; Mark,Cushman ^[4]

作者单位： Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and The Purdue University Center for Cancer Research, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, United States; School of Chemistry and Chemical Engineering, and Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou 221116, Jiangsu, China. ^[1] Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indiana Institute for Personalized Medicine, Indianapolis, IN 46202, United States. ^[2] Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and The Purdue University Center for Cancer Research, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, United States. ^[3] Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and The Purdue University Center for Cancer Research, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, United States. Electronic address: cushman@purdue.edu. ^[4]

关键词 (E,Z)-Norendoxifen synthesis Antiestrogenic activity Aromatase inhibitor Breast cancer Estrogen receptor