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VEGF induces signalling and angiogenesis by directing VEGFR2 internalisation through macropinocytosis.

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第一作者： Dimitris,Basagiannis

第一单位： Institute of Molecular Biology and Biotechnology-Biomedical Research, Foundation for Research and Technology, Ioannina 45110, Greece.;Laboratory of Biological Chemistry, Department of Medicine, School of Health Sciences, University of Ioannina, Ioannina 45110, Greece.

作者： Dimitris,Basagiannis ^[1] ; Sofia,Zografou ^[2] ; Carol,Murphy ^[3] ; Theodore,Fotsis ^[1] ; Lucia,Morbidelli ^[4] ; Marina,Ziche ^[4] ; Christopher,Bleck ^[5] ; Jason,Mercer ^[6] ; Savvas,Christoforidis ^[7]

作者单位： Institute of Molecular Biology and Biotechnology-Biomedical Research, Foundation for Research and Technology, Ioannina 45110, Greece.;Laboratory of Biological Chemistry, Department of Medicine, School of Health Sciences, University of Ioannina, Ioannina 45110, Greece. ^[1] Institute of Molecular Biology and Biotechnology-Biomedical Research, Foundation for Research and Technology, Ioannina 45110, Greece. ^[2] Institute of Molecular Biology and Biotechnology-Biomedical Research, Foundation for Research and Technology, Ioannina 45110, Greece.;School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. ^[3] Department of Life Sciences, University of Siena, Via Aldo Moro 2, Siena 53100, Italy. ^[4] Institute of Biochemistry, ETH, Zurich 8093, Switzerland. ^[5] Institute of Biochemistry, ETH, Zurich 8093, Switzerland.;MRC-Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK. ^[6] Institute of Molecular Biology and Biotechnology-Biomedical Research, Foundation for Research and Technology, Ioannina 45110, Greece savvas_christoforidis@imbb.forth.gr schristo@uoi.gr.;Laboratory of Biological Chemistry, Department of Medicine, School of Health Sciences, University of Ioannina, Ioannina 45110, Greece. ^[7]

关键词 Endocytosis Macropinocytosis Membrane trafficking Signalling VEGF VEGFR2