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Microbially produced glucagon-like peptide 1 improves glucose tolerance in mice.

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第一作者： Tulika,Arora

第一单位： Wallenberg Laboratory and Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.

作者： Tulika,Arora ^[1] ; Udo,Wegmann ^[2] ; Anup,Bobhate ^[2] ; Ying Shiuan,Lee ^[1] ; Thomas U,Greiner ^[1] ; Daniel J,Drucker ^[3] ; Arjan,Narbad ^[2] ; Fredrik,Bäckhed ^[4]

作者单位： Wallenberg Laboratory and Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden. ^[1] Gut Health and Food Safety Programme, Institute of Food Research, Norwich NR4 7UA, UK. ^[2] Department of Medicine, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON M5G 1X5, Canada. ^[3] Wallenberg Laboratory and Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden; Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Receptology and Enteroendocrinology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: Fredrik.Backhed@wlab.gu.se. ^[4]

关键词 DPP4, Dipeptidyl peptidase 4 G-KRB, glucose-Krebs ringer buffer G6pc, glucose 6 phosphatase, catalytic subunit GLP-1 GLP-1, Glucagon-like peptide 1 GLP1R-KO, GLP-1 receptor knock out Glucose tolerance HFD, high fat diet IPGTT, Intraperitoneal glucose tolerance test ITT, Insulin tolerance test LL-GLP1, GLP-1 producing recombinant strain LL-UK200, Control vector only strain Lactococcus lactis Pepck, phosphoenolpyruvate carboxykinase Recombinant bacteria WT, Wild type cfu, Colony forming unit

DOI 10.1016/j.molmet.2016.06.006

PMID 27656410

发布时间 2025-05-30

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Molecular metabolism

2016年5卷8期

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Microbially produced glucagon-like peptide 1 improves glucose tolerance in mice.

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Microbially produced glucagon-like peptide 1 improves glucose tolerance in mice.

Molecular metabolism

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