Anti-inflammatory activity of Barleria lupulina: Identification of active compounds that activate the Nrf2 cell defense pathway, organize cortical actin, reduce stress fibers, and improve cell junctions in microvascular endothelial cells.
第一作者:
Donald R,Senger
第一单位:
Department of Pathology and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
作者:
关键词
4-Ethylcatechol4-Ethylcatechol (PubChem CID: 70761)4-Methylcatechol4-Methylcatehcol (PubChem CID: 9958)4-Vinylcatechol4-Vinylcatechol (PubChem CID: 151398)Actin cytoskeletonBarleria lupulinaCaffeic acid (PubChem CID: 689043)Endothelial barrier functionMicrovascular endothelial cellsNrf2Poliumoside (PubChem CID: 6442411)Shanzhiside methyl ester (PubChem CID: 13892722)Traditional medicine
主题词
爵床科(Acanthaceae);肌动蛋白类(Actins);消炎药(Anti-Inflammatory Agents);儿茶酚类(Catechols);细胞, 培养的(Cells, Cultured);内皮细胞(Endothelial Cells);人类(Humans);炎症(Inflammation);微血管(Microvessels);NF-E2相关因子2(NF-E2-Related Factor 2);植物药疗法(Phytotherapy);植物组成部分, 地上(Plant Components, Aerial);植物提取物(Plant Extracts);植物, 药用(Plants, Medicinal);信号传导(Signal Transduction);张力纤维(Stress Fibers);紧密连接部(Tight Junctions);时间因素(Time Factors);增量调节(Up-Regulation)
DOI
10.1016/j.jep.2016.09.017
PMID
27660013
发布时间
2019-01-09
- 浏览20
Journal of ethnopharmacology
397-407页
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