Discovery of 5-Phenyl-N-(pyridin-2-ylmethyl)-2-(pyrimidin-5-yl)quinazolin-4-amine as a Potent I Kur Inhibitor.

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作者： Heather J,Finlay ^[1] ; James A,Johnson ^[1] ; John L,Lloyd ^[1] ; Ji,Jiang ^[1] ; James,Neels ^[1] ; Prashantha,Gunaga ^[2] ; Abhisek,Banerjee ^[2] ; Naveen,Dhondi ^[2] ; Anjaneya,Chimalakonda ^[1] ; Sandhya,Mandlekar ^[2] ; Mary Lee,Conder ^[1] ; Harinath,Sale ^[2] ; Dezhi,Xing ^[1] ; Paul,Levesque ^[1] ; Ruth R,Wexler ^[1]

作者单位： Departments of Discovery Chemistry, Biology, and Preclinical Candidate Optimization, Bristol-Myers Squibb, Research and Development , P.O. Box 5400, Princeton, New Jersey 08543-5400, United States. ^[1] Departments of Discovery Chemistry, Biology, and Preclinical Candidate Optimization, Biocon Bristol-Myers Squibb Research Center (BBRC) , Bangalore 560099, India. ^[2]

关键词 Kv 1.5 atrial effective refractory period phenylquinazoline ventricular effective refractory period

DOI 10.1021/acsmedchemlett.6b00117

PMID 27660686

发布时间 2020-10-01

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