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Type I interferon causes thrombotic microangiopathy by a dose-dependent toxic effect on the microvasculature.

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第一作者： David,Kavanagh

第一单位： National Renal Complement Therapeutics Centre, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.

作者： David,Kavanagh ^[1] ; Sarah,McGlasson ^[2] ; Alexa,Jury ^[2] ; Jac,Williams ^[3] ; Neil,Scolding ^[4] ; Chris,Bellamy ^[5] ; Claudia,Gunther ^[6] ; Diane,Ritchie ^[3] ; Daniel P,Gale ^[7] ; Yashpal S,Kanwar ^[8] ; Rachel,Challis ^[1] ; Holly,Buist ^[9] ; James,Overell ^[10] ; Belinda,Weller ^[3] ; Oliver,Flossmann ^[11] ; Mark,Blunden ^[12] ; Eric P,Meyer ^[13] ; Thomas,Krucker ^[14] ; Stephen J W,Evans ^[15] ; Iain L,Campbell ^[16] ; Andrew P,Jackson ^[2] ; Siddharthan,Chandran ^[3] ; David P J,Hunt ^[17]

作者单位： National Renal Complement Therapeutics Centre, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom. ^[1] Medical Research Council Institute of Genetics and Molecular Medicine and. ^[2] Centre for Clinical Brain Sciences, Edinburgh University, Edinburgh, United Kingdom. ^[3] Institute of Clinical Neurosciences, University of Bristol, Bristol, United Kingdom. ^[4] Department of Renal Medicine, University of Edinburgh, Edinburgh, United Kingdom. ^[5] Department of Dermatology, University Hospital, Technical University Dresden, Dresden, Germany. ^[6] Centre for Nephrology, Royal Free Hospital, University College London, London, United Kingdom. ^[7] Feinberg School of Medicine, Northwestern University, Chicago, IL. ^[8] Department of Cellular Pathology, Royal Victoria Hospital, Newcastle upon Tyne, United Kingdom. ^[9] Institute of Neurological Sciences, Glasgow University, Glasgow, United Kingdom. ^[10] Royal Berkshire Hospital, Reading, United Kingdom. ^[11] Barts and the London National Health Service Trust, London, United Kingdom. ^[12] Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland. ^[13] The Scripps Research Institute, La Jolla, CA. ^[14] London School of Hygiene & Tropical Medicine, London, United Kingdom; and. ^[15] School of Molecular Bioscience, University of Sydney, Sydney, Australia. ^[16] Medical Research Council Institute of Genetics and Molecular Medicine and.;Centre for Clinical Brain Sciences, Edinburgh University, Edinburgh, United Kingdom. ^[17]