A versatile strategy for the design and synthesis of novel ADP conjugates and their evaluation as potential poly(ADP-ribose) polymerase 1 inhibitors.

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作者： Yuliya V,Sherstyuk ^[1] ; Alexandra L,Zakharenko ^[1] ; Mikhail M,Kutuzov ^[1] ; Polina V,Chalova ^[1] ; Maria V,Sukhanova ^[2] ; Olga I,Lavrik ^[1] ; Vladimir N,Silnikov ^[2] ; Tatyana V,Abramova ^[1]

作者单位： Institute of Chemical Biology and Fundamental Medicine, SB RAS, Lavrent'ev Ave., 8, Novosibirsk, 630090, Russia. ^[1] Novosibirsk State University, Pirogova St., 2, Novosibirsk, 630090, Russia. ^[2] Institute of Chemical Biology and Fundamental Medicine, SB RAS, Lavrent'ev Ave., 8, Novosibirsk, 630090, Russia. abramova@niboch.nsc.ru. ^[3]

关键词 PARP inhibitors PARP-1 Pyrophosphate synthesis analogues

主题词腺苷二磷酸(Adenosine Diphosphate);仿生材料(Biomimetic Materials);药物设计(Drug Design);酶抑制剂(Enzyme Inhibitors);NAD(NAD)

DOI 10.1007/s11030-016-9703-x

PMID 27677737

发布时间 2018-11-13

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