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Patient-derived Mammosphere and Xenograft Tumour Initiation Correlates with Progression to Metastasis.

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第一作者： Rachel,Eyre

第一单位： Breast Biology Group, Breast Cancer Now Research Unit, Division of Molecular and Clinical Cancer Sciences, Manchester Cancer Research Centre, University of Manchester, Wilmslow Road, Manchester, M20 4QL, UK.

作者： Rachel,Eyre ^[1] ; Denis G,Alférez ^[1] ; Kath,Spence ^[1] ; Mohamed,Kamal ^[2] ; Frances L,Shaw ^[1] ; Bruno M,Simões ^[1] ; Angélica,Santiago-Gómez ^[1] ; Aida,Sarmiento-Castro ^[1] ; Maria,Bramley ^[3] ; Mohammed,Absar ^[3] ; Zahida,Saad ^[4] ; Sumohan,Chatterjee ^[4] ; Cliona,Kirwan ^[5] ; Ashu,Gandhi ^[5] ; Anne C,Armstrong ^[6] ; Andrew M,Wardley ^[6] ; Ciara S,O'Brien ^[6] ; Gillian,Farnie ^[7] ; Sacha J,Howell ^[8] ; Robert B,Clarke ^[9]

作者单位： Breast Biology Group, Breast Cancer Now Research Unit, Division of Molecular and Clinical Cancer Sciences, Manchester Cancer Research Centre, University of Manchester, Wilmslow Road, Manchester, M20 4QL, UK. ^[1] Breast Biology Group, Breast Cancer Now Research Unit, Division of Molecular and Clinical Cancer Sciences, Manchester Cancer Research Centre, University of Manchester, Wilmslow Road, Manchester, M20 4QL, UK.;Department of Zoology, Faculty of Science, University of Benha, Benha, Egypt. ^[2] Pennine Acute Hospitals NHS Trust, Manchester, UK. ^[3] Salford Royal NHS Foundation Trust, Manchester, UK. ^[4] University Hospitals of South Manchester NHS Foundation Trust, Manchester, UK. ^[5] The Christie NHS Foundation Trust, Wilmslow Road, Manchester, M20 4BX, UK. ^[6] Cancer Stem Cell Research, Division of Molecular and Clinical Cancer Sciences, Manchester Cancer Research Centre, University of Manchester, Wilmslow Road, Manchester, M20 4QL, UK. ^[7] The Christie NHS Foundation Trust, Wilmslow Road, Manchester, M20 4BX, UK.;Breast Cancer Now Research Unit, Division of Molecular and Clinical Cancer Sciences, Manchester Cancer Research Centre, University of Manchester, Wilmslow Road, Manchester, M20 4QL, UK. ^[8] Breast Biology Group, Breast Cancer Now Research Unit, Division of Molecular and Clinical Cancer Sciences, Manchester Cancer Research Centre, University of Manchester, Wilmslow Road, Manchester, M20 4QL, UK. robert.clarke@manchester.ac.uk. ^[9]

关键词 Breast cancer Mammosphere Metastasis Patient-derived xenografts Stem cell activity