作者：
James Rush,Priest [1]
;
Charles,Gawad [2]
;
Kristopher M,Kahlig [3]
;
Joseph K,Yu [4]
;
Thomas,O'Hara [5]
;
Patrick M,Boyle [4]
;
Sridharan,Rajamani [3]
;
Michael J,Clark [6]
;
Sarah T K,Garcia [6]
;
Scott,Ceresnak [1]
;
Jason,Harris [6]
;
Sean,Boyle [6]
;
Frederick E,Dewey [7]
;
Lindsey,Malloy-Walton [1]
;
Kyla,Dunn [8]
;
Megan,Grove [7]
;
Marco V,Perez [7]
;
Norma F,Neff [9]
;
Richard,Chen [6]
;
Katsuhide,Maeda [10]
;
Anne,Dubin [1]
;
Luiz,Belardinelli [3]
;
John,West [6]
;
Christian,Antolik [11]
;
Daniela,Macaya [11]
;
Thomas,Quertermous [7]
;
Natalia A,Trayanova [4]
;
Stephen R,Quake [12]
;
Euan A,Ashley [13]
作者单位：
Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Stanford, CA 94305; Child Health Research Institute, Stanford University School of Medicine, Stanford, CA 94305; Division of Pediatric Cardiology, Stanford University School of Medicine, Stanford, CA 94305.
[1]
Child Health Research Institute, Stanford University School of Medicine, Stanford, CA 94305; Division of Pediatric Hematology-Oncology, Stanford University School of Medicine, Stanford, CA 94305.
[2]
Department of Biology, Cardiovascular Therapeutic Area, Gilead Sciences, Fremont, CA 94555.
[3]
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218; Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD 21218.
[4]
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218.
[5]
Personalis, Inc., Menlo Park, CA 94025.
[6]
Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Stanford, CA 94305; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305.
[7]
Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Stanford, CA 94305; Lucile Packard Children's Hospital Heart Center, Palo Alto, CA 94304.
[8]
Department of Bioengineering, Stanford University School of Medicine, Stanford, CA 94305.
[9]
Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Stanford, CA 94305; Division of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305.
[10]
Cardiogenetic Testing Services, GeneDx, Gaithersburg, MD 20877.
[11]
Department of Bioengineering, Stanford University School of Medicine, Stanford, CA 94305; Department of Applied Physics, Stanford University, Stanford, CA 94305; Howard Hughes Medical Research Institute, Stanford University School of Medicine, Stanford, CA 94305 euan@stanford.edu quake@stanford.edu.
[12]
Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Stanford, CA 94305; Child Health Research Institute, Stanford University School of Medicine, Stanford, CA 94305; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305; euan@stanford.edu quake@stanford.edu.
[13]
主题词
动作电位(Action Potentials);心律失常, 心性(Arrhythmias, Cardiac);碱基序列(Base Sequence);心肌病, 扩张型(Cardiomyopathy, Dilated);计算机模拟(Computer Simulation);扩散(Diffusion);心电描记术(Electrocardiography);基因频率(Gene Frequency);基因, 显性(Genes, Dominant);基因座(Genetic Loci);疾病遗传易感性(Genetic Predisposition to Disease);心脏传导系统(Heart Conduction System);高通量核苷酸序列分析(High-Throughput Nucleotide Sequencing);人类(Humans);婴儿(Infant);离子通道闸门(Ion Channel Gating);QT延长综合征(Long QT Syndrome);模型, 生物学(Models, Biological);镶嵌现象(Mosaicism);突变(Mutation);肌细胞, 心脏(Myocytes, Cardiac);表型(Phenotype);单细胞分析(Single-Cell Analysis)
DOI
10.1073/pnas.1607187113
PMID
27681629
发布时间
2020-07-21
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