Stereoselective Blockage of Quinidine and Quinine in the hERG Channel and the Effect of Their Rescue Potency on Drug-Induced hERG Trafficking Defect.

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作者： Meng,Yan ^[1] ; Pan,Fan ^[2] ; Yanhui,Shi ^[3] ; Lifang,Feng ^[4] ; Junnan,Wang ^[5] ; Ge,Zhan ^[6] ; Baoxin,Li ^[7]

作者单位： Department of Pharmacology, Harbin Medical University, No. 194 Xuefu Road, Nangang District, Harbin 150081, China. yanmeng1214@163.com. ^[1] Department of Ophthalmology, the Second Affiliated Hospital, Harbin Medical University, No. 148 Baojian Road, Nangang District, Harbin 150081, China. di20071214@163.com. ^[2] Department of Pharmacology, Harbin Medical University, No. 194 Xuefu Road, Nangang District, Harbin 150081, China. shiyanhuihao123@163.com. ^[3] Department of Pharmacology, Harbin Medical University, No. 194 Xuefu Road, Nangang District, Harbin 150081, China. fmlff123@163.com. ^[4] Department of Pharmacology, Harbin Medical University, No. 194 Xuefu Road, Nangang District, Harbin 150081, China. wangjunnan0611@163.com. ^[5] Department of Pharmacology, Harbin Medical University, No. 194 Xuefu Road, Nangang District, Harbin 150081, China. zhange0403@163.com. ^[6] Department of Pharmacology, Harbin Medical University, No. 194 Xuefu Road, Nangang District, Harbin 150081, China. libx64@hotmail.com. ^[7]

关键词 hERG (human ether-a-go-go-related gene)pharmacological rescue quinidine quinine stereoselectivity

DOI 10.3390/ijms17101648

PMID 27690007

发布时间 2019-11-20

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