Synthesis of Complex Druglike Molecules by the Use of Highly Functionalized Bench-Stable Organozinc Reagents.

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作者： Thomas J,Greshock ^[1] ; Keith P,Moore ^[2] ; Ray T,McClain ^[2] ; Ana,Bellomo ^[2] ; Cheol K,Chung ^[2] ; Spencer D,Dreher ^[2] ; Peter S,Kutchukian ^[2] ; Zhengwei,Peng ^[2] ; Ian W,Davies ^[2] ; Petr,Vachal ^[2] ; Mario,Ellwart ^[3] ; Sophia M,Manolikakes ^[3] ; Paul,Knochel ^[4] ; Philippe G,Nantermet ^[2]

作者单位： Discovery Chemistry, Process Chemistry, and Structural Chemistry, Merck Research Laboratories, Merck & Co., Inc., West Point, PA, 19486, USA. thomas_greshock@merck.com. ^[1] Discovery Chemistry, Process Chemistry, and Structural Chemistry, Merck Research Laboratories, Merck & Co., Inc., West Point, PA, 19486, USA. ^[2] Ludwig-Maximilians-Universität München, Department Chemie, Butenandtstrasse 5-13, Haus F, 81377, München, Germany. ^[3] Ludwig-Maximilians-Universität München, Department Chemie, Butenandtstrasse 5-13, Haus F, 81377, München, Germany. paul.knochel@cup.uni-muenchen.de. ^[4]

关键词 druglike molecules high-throughput screening late-stage functionalization medicinal chemistry organozinc reagents

主题词高通量筛选分析(High-Throughput Screening Assays);分子结构(Molecular Structure);有机金属化合物(Organometallic Compounds);主成分分析(Principal Component Analysis);吡啶类(Pyridines);锌(Zinc)

DOI 10.1002/anie.201604652

PMID 27690172

发布时间 2018-08-28

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