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首页> Free radical biology & medicine> Perturbation of redox balance after thioredoxin reductase deficiency interrupts autophagy-lysosomal degradation pathway and enhances cell death in nutritionally stressed SH-SY5Y cells.

Perturbation of redox balance after thioredoxin reductase deficiency interrupts autophagy-lysosomal degradation pathway and enhances cell death in nutritionally stressed SH-SY5Y cells.

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作者： Pandian,Nagakannan ^[1] ; Mohamed Ariff,Iqbal ^[1] ; Albert,Yeung ^[1] ; James A,Thliveris ^[2] ; Mojgan,Rastegar ^[3] ; Saeid,Ghavami ^[2] ; Eftekhar,Eftekharpour ^[1]

作者单位： Spinal Cord Research Center, Department of Physiology and Pathophysiology, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada; Regenerative Medicine Program, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. ^[1] Department of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. ^[2] Department of Biochemistry & Medical Genetics, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada; Regenerative Medicine Program, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. ^[3]

关键词 Autophagy-Apotosis Interplay Lysosome Neurodegenerative disease Proteasome Redox Regulation Ubiquitination

主题词乙酰半胱氨酸(Acetylcysteine);抗氧化剂(Antioxidants);细胞凋亡(Apoptosis);自噬(Autophagy);细胞系, 肿瘤(Cell Line, Tumor);培养基, 无血清(Culture Media, Serum-Free);基因表达调控(Gene Expression Regulation);遗传载体(Genetic Vectors);人类(Humans);慢病毒属(Lentivirus);溶酶体(Lysosomes);神经元(Neurons);氧化还原(Oxidation-Reduction);吞噬体(Phagosomes);蛋白酶体内肽酶复合物(Proteasome Endopeptidase Complex);RNA, 小分子干扰(RNA, Small Interfering);活性氧(Reactive Oxygen Species);硫氧还蛋白还原酶1(Thioredoxin Reductase 1)

DOI 10.1016/j.freeradbiomed.2016.09.026

PMID 27693380

发布时间 2023-12-13

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Free radical biology & medicine

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