Regional expression of the MAPT gene is associated with loss of hubs in brain networks and cognitive impairment in Parkinson disease and progressive supranuclear palsy.

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第一作者： Timothy,Rittman

第一单位： Department of Clinical Neurosciences, University of Cambridge, Herchel Smith Building for Brain and Mind Sciences, Cambridge, UK; Department of Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK. Electronic address: tr332@medschl.cam.ac.uk.

作者： Timothy,Rittman ^[1] ; Mikail,Rubinov ^[2] ; Petra E,Vértes ^[3] ; Ameera X,Patel ^[3] ; Cedric E,Ginestet ^[4] ; Boyd C P,Ghosh ^[5] ; Roger A,Barker ^[6] ; Maria Grazia,Spillantini ^[7] ; Edward T,Bullmore ^[3] ; James B,Rowe ^[8]

作者单位： Department of Clinical Neurosciences, University of Cambridge, Herchel Smith Building for Brain and Mind Sciences, Cambridge, UK; Department of Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK. Electronic address: tr332@medschl.cam.ac.uk. ^[1] Department of Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK; Department of Psychiatry, Herchel Smith Building for Brain and Mind Sciences, Cambridge, UK; Churchill College, University of Cambridge, Cambridge, UK. ^[2] Department of Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK; Department of Psychiatry, Herchel Smith Building for Brain and Mind Sciences, Cambridge, UK. ^[3] Department of Biostatistics, Institute of Psychiatry Psychology and Neuroscience, King's College London, London, UK. ^[4] Wessex Neurological Centre, University Hospital Southampton, Southampton, UK. ^[5] Department of Clinical Neurosciences, University of Cambridge, Herchel Smith Building for Brain and Mind Sciences, Cambridge, UK; Department of Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK; John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, UK. ^[6] Department of Clinical Neurosciences, University of Cambridge, Herchel Smith Building for Brain and Mind Sciences, Cambridge, UK; John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, UK. ^[7] Department of Clinical Neurosciences, University of Cambridge, Herchel Smith Building for Brain and Mind Sciences, Cambridge, UK; Department of Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK; Medical Research Council Cognition and Brain Sciences Unit, Cambridge, UK. ^[8]

关键词 Brain imaging Functional connectivity Gene expression Parkinson's disease Progressive supranuclear palsy Tau