One-time injection of AAV8 encoding urocortin 2 provides long-term resolution of insulin resistance.

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作者： Mei Hua,Gao ^[1] ; Dimosthenis,Giamouridis ^[1] ; N Chin,Lai ^[2] ; Evelyn,Walenta ^[1] ; Vivian Almeida,Paschoal ^[2] ; Young Chul,Kim ^[1] ; Atsushi,Miyanohara ^[2] ; Tracy,Guo ^[1] ; Min,Liao ^[3] ; Li,Liu ^[4] ; Zhen,Tan ^[1] ; Theodore P,Ciaraldi ^[1] ; Simon,Schenk ^[5] ; Aditi,Bhargava ^[3] ; Da Young,Oh ^[2] ; H Kirk,Hammond ^[1]

作者单位： VA San Diego Healthcare System, San Diego, California, USA.;Department of Medicine, UCSD, San Diego, California, USA. ^[1] Department of Medicine, UCSD, San Diego, California, USA. ^[2] Department of Ob-Gyn and The Osher Center for Integrative Medicine, UCSF, San Francisco, California, USA. ^[3] Department of Ob-Gyn and The Osher Center for Integrative Medicine, UCSF, San Francisco, California, USA.;Department of Medicine, First Hospital of Qinhuangdao, Hebei Province, China. ^[4] Department of Orthopedic Surgery, UCSD, San Diego, California, USA. ^[5]

主题词动物(Animals);血糖(Blood Glucose);依赖病毒(Dependovirus);女(雌)性(Female);遗传载体(Genetic Vectors);胰岛素抗药性(Insulin Resistance);男(雄)性(Male);小鼠(Mice);受体, 促肾上腺皮质素释放激素(Receptors, Corticotropin-Releasing Hormone);尿皮质素类(Urocortins)

DOI 10.1172/jci.insight.88322

PMID 27699250

发布时间 2024-09-22

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One-time injection of AAV8 encoding urocortin 2 provides long-term resolution of insulin resistance.

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One-time injection of AAV8 encoding urocortin 2 provides long-term resolution of insulin resistance.

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