Paneth cell defects in Crohn's disease patients promote dysbiosis.

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第一作者： Ta-Chiang,Liu

第一单位： Department of Pathology and Immunology, Washington University, Saint Louis, Missouri, USA.

作者： Ta-Chiang,Liu ^[1] ; Bhaskar,Gurram ^[2] ; Megan T,Baldridge ^[1] ; Richard,Head ^[3] ; Vy,Lam ^[2] ; Chengwei,Luo ^[4] ; Yumei,Cao ^[5] ; Pippa,Simpson ^[5] ; Michael,Hayward ^[2] ; Mary L,Holtz ^[2] ; Pavlos,Bousounis ^[2] ; Joshua,Noe ^[2] ; Diana,Lerner ^[2] ; Jose,Cabrera ^[2] ; Vincent,Biank ^[2] ; Michael,Stephens ^[2] ; Curtis,Huttenhower ^[6] ; Dermot Pb,McGovern ^[7] ; Ramnik J,Xavier ^[8] ; Thaddeus S,Stappenbeck ^[1] ; Nita H,Salzman ^[2]

作者单位： Department of Pathology and Immunology, Washington University, Saint Louis, Missouri, USA. ^[1] Department of Pediatrics, Division of Gastroenterology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA. ^[2] Genome Technology Access Center, Washington University, Saint Louis, Missouri, USA. ^[3] The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. ^[4] Department of Pediatrics, Division of Quantitative Health Services, Medical College of Wisconsin, Milwaukee, Wisconsin, USA. ^[5] The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.;Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. ^[6] The F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA. ^[7] The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.;Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, Massachusetts, USA. ^[8]

主题词青少年(Adolescent);儿童(Child);儿童, 学龄前(Child, Preschool);Crohn病(Crohn Disease);人类(Humans);回肠(Ileum);肠黏膜(Intestinal Mucosa);帕内特细胞(Paneth Cells)

DOI 10.1172/jci.insight.86907

PMID 27699268

发布时间 2019-05-08

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Paneth cell defects in Crohn's disease patients promote dysbiosis.

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Paneth cell defects in Crohn's disease patients promote dysbiosis.

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