Facile modulation of enantioselectivity of thermophilic Geobacillus zalihae lipase by regulating hydrophobicity of its Q114 oxyanion.

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第一作者： Roswanira,Abdul Wahab

第一单位： Dept. of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310, Johor Bahru,Malaysia. Electronic address: roswanira@kimia.fs.utm.my.

作者： Roswanira,Abdul Wahab ^[1] ; Mahiran,Basri ^[2] ; Raja Noor Zaliha,Raja Abdul Rahman ^[3] ; Abu Bakar,Salleh ^[4] ; Mohd Basyaruddin,Abdul Rahman ^[5] ; Thean Chor,Leow ^[6]

作者单位： Dept. of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310, Johor Bahru,Malaysia. Electronic address: roswanira@kimia.fs.utm.my. ^[1] Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia; Enzyme and Microbial Technology Research Center, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia. Electronic address: mahiran@upm.edu.my. ^[2] Department of Microbiology, Faculty of Biotechnology and Biomolecular Science, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia; Enzyme and Microbial Technology Research Center, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia; Institute of Bioscience, Universiti Putra Malaysia, 43400, UPM Serdang, Selangor, Malaysia. ^[3] Department of Biochemistry, Faculty of Biotechnology and Biomolecular Science, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia; Enzyme and Microbial Technology Research Center, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia; Institute of Bioscience, Universiti Putra Malaysia, 43400, UPM Serdang, Selangor, Malaysia. ^[4] Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia; Enzyme and Microbial Technology Research Center, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia. ^[5] Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Science, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia; Enzyme and Microbial Technology Research Center, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia; Institute of Bioscience, Universiti Putra Malaysia, 43400, UPM Serdang, Selangor, Malaysia. ^[6]

关键词 2DSN Enantioselectivity Geobacillus zalihae Oxyanion Site-directed mutagenesis T1 lipase