Loss and Gain of Human Acidic Mammalian Chitinase Activity by Nonsynonymous SNPs.

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作者： Kazuaki,Okawa ^[1] ; Misa,Ohno ^[1] ; Akinori,Kashimura ^[1] ; Masahiro,Kimura ^[1] ; Yuki,Kobayashi ^[1] ; Masayoshi,Sakaguchi ^[1] ; Yasusato,Sugahara ^[1] ; Minori,Kamaya ^[2] ; Yoshihiro,Kino ^[3] ; Peter O,Bauer ^[4] ; Fumitaka,Oyama ^[5]

作者单位： Department of Chemistry and Life Science, Kogakuin University, Hachioji, Tokyo, Japan. ^[1] Department of Applied Chemistry, Kogakuin University, Hachioji, Tokyo, Japan. ^[2] Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University, Kiyose, Tokyo, Japan. ^[3] Department of Neuroscience, Mayo Clinic, Jacksonville, FL. ^[4] Department of Chemistry and Life Science, Kogakuin University, Hachioji, Tokyo, Japan f-oyama@cc.kogakuin.ac.jp. ^[5]

关键词 acidic mammalian chitinase amino acid substitutions chitinolytic activity pseudogene reactivation single-nucleotide polymorphisms

主题词动物(Animals);哮喘(Asthma);人类(Humans);小鼠(Mice);突变, 误义(Mutation, Missense);多态性, 单核苷酸(Polymorphism, Single Nucleotide)

DOI 10.1093/molbev/msw198

PMID 27702777

发布时间 2018-11-13

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准确一般字义偏差语意偏离译文作用小提交