p21<sup>Cip1</sup> plays a critical role in the physiological adaptation to fasting through activation of PPARα.

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第一作者： Elena,Lopez-Guadamillas

第一单位： Tumor Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid E28029, Spain.

作者： Elena,Lopez-Guadamillas ^[1] ; Pablo J,Fernandez-Marcos ^[2] ; Cristina,Pantoja ^[1] ; Maribel,Muñoz-Martin ^[1] ; Dolores,Martínez ^[3] ; Gonzalo,Gómez-López ^[4] ; Ramón,Campos-Olivas ^[5] ; Angela M,Valverde ^[6] ; Manuel,Serrano ^[1]

作者单位： Tumor Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid E28029, Spain. ^[1] Tumor Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid E28029, Spain.;Bioactive Products and Metabolic Syndrome Group, Madrid Institute of Advanced Studies (IMDEA) in Food, CEI UAM+CSIC, Madrid E28049, Spain. ^[2] Flow Cytometry Unit, Spanish National Cancer Research Centre (CNIO), Madrid E28029, Spain. ^[3] Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), Madrid E28029, Spain. ^[4] Spectroscopy and Nuclear Magnetic Resonance Unit, Spanish National Cancer Research Centre (CNIO), Madrid E28029, Spain. ^[5] Instituto de Investigaciones Biomédicas "Alberto Sols" (CSIC/UAM), Madrid E28029, Spain.;Centro de Investigaciones Biomédicas en Red de Diabetes y Enfermedades Metabólicas Asociadas, ISCIII, Spain. ^[6]

主题词适应, 生理学(Adaptation, Physiological);动物(Animals);周期素依赖激酶抑制剂p21(Cyclin-Dependent Kinase Inhibitor p21);禁食(Fasting);男(雄)性(Male);小鼠(Mice);小鼠, 突变型(Mice, Mutant Strains);PPARα(PPAR alpha);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53)

DOI 10.1038/srep34542

PMID 27721423

发布时间 2018-11-13

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p21<sup>Cip1</sup> plays a critical role in the physiological adaptation to fasting through activation of PPARα.

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p21<sup>Cip1</sup> plays a critical role in the physiological adaptation to fasting through activation of PPARα.

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