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Selective inhibition of Sarcocystis neurona calcium-dependent protein kinase 1 for equine protozoal myeloencephalitis therapy.

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第一作者： Kayode K,Ojo

第一单位： Department of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Reemerging Infectious Disease (CERID), University of Washington, Seattle, WA 98109, USA. Electronic address: ojo67kk@u.washington.edu.

作者： Kayode K,Ojo ^[1] ; Sriveny,Dangoudoubiyam ^[2] ; Shiv K,Verma ^[3] ; Suzanne,Scheele ^[4] ; Amy E,DeRocher ^[4] ; Michelle,Yeargan ^[5] ; Ryan,Choi ^[6] ; Tess R,Smith ^[6] ; Kasey L,Rivas ^[6] ; Matthew A,Hulverson ^[6] ; Lynn K,Barrett ^[6] ; Erkang,Fan ^[7] ; Dustin J,Maly ^[8] ; Marilyn,Parsons ^[9] ; Jitender P,Dubey ^[3] ; Daniel K,Howe ^[10] ; Wesley C,Van Voorhis ^[11]

作者单位： Department of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Reemerging Infectious Disease (CERID), University of Washington, Seattle, WA 98109, USA. Electronic address: ojo67kk@u.washington.edu. ^[1] Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA. ^[2] United States Department of Agriculture, Agricultural Research Service, Beltsville Agricultural Research Center, Animal Parasitic Diseases Laboratory, Beltsville, MD 20705, USA. ^[3] Center for Infectious Disease Research, Seattle, WA 98109, USA. ^[4] Department of Veterinary Science, University of Kentucky, Lexington, KY 40546, USA. ^[5] Department of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Reemerging Infectious Disease (CERID), University of Washington, Seattle, WA 98109, USA. ^[6] Department of Biochemistry, University of Washington, Seattle, WA 98195, USA. ^[7] Department of Chemistry, University of Washington, Seattle, WA 98195, USA. ^[8] Center for Infectious Disease Research, Seattle, WA 98109, USA; Department of Global Health, University of Washington, Seattle, WA 98195, USA. ^[9] Department of Veterinary Science, University of Kentucky, Lexington, KY 40546, USA. Electronic address: daniel.howe@uky.edu. ^[10] Department of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Reemerging Infectious Disease (CERID), University of Washington, Seattle, WA 98109, USA; Department of Global Health, University of Washington, Seattle, WA 98195, USA. Electronic address: wesley@uw.edu. ^[11]

关键词 Bumped kinase inhibitors Calcium-dependent protein kinase 1 Drug target Equine protozoal myeloencephalitis Gatekeeper residue Sarcocystis neurona