Methazolamide improves neurological behavior by inhibition of neuron apoptosis in subarachnoid hemorrhage mice.

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作者： Mingchang,Li ^[1] ; Wei,Wang ^[2] ; Haojian,Mai ^[1] ; Xinmu,Zhang ^[3] ; Jian,Wang ^[2] ; Yufeng,Gao ^[2] ; Yuefei,Wang ^[4] ; Gang,Deng ^[1] ; Ling,Gao ^[1] ; Shuanhu,Zhou ^[5] ; Qianxue,Chen ^[6] ; Xin,Wang ^[1]

作者单位： Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, P. R. China. ^[1] Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA. ^[2] Department of Neurosurgery, Baoan District Hospital, Shenzhen, Guangdong, 518100, P. R. China. ^[3] Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA. ^[4] Department of Endocrinology, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, P. R. China. ^[5] Department of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA. ^[6]

主题词动物(Animals);细胞凋亡(Apoptosis);血脑屏障(Blood-Brain Barrier);脑水肿(Brain Edema);半胱氨酸天冬氨酸蛋白酶3(Caspase 3);大脑皮质(Cerebral Cortex);认知障碍(Cognition Disorders);疾病模型, 动物(Disease Models, Animal);基因表达调控(Gene Expression Regulation);男(雄)性(Male);醋甲唑胺(Methazolamide);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);神经元(Neurons);活性氧(Reactive Oxygen Species);蛛网膜下腔出血(Subarachnoid Hemorrhage);血管痉挛, 颅内(Vasospasm, Intracranial)

DOI 10.1038/srep35055

PMID 27731352

发布时间 2018-11-13

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Methazolamide improves neurological behavior by inhibition of neuron apoptosis in subarachnoid hemorrhage mice.

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Methazolamide improves neurological behavior by inhibition of neuron apoptosis in subarachnoid hemorrhage mice.

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