Persistent neuroinflammation and cognitive impairment in a rat model of acute diisopropylfluorophosphate intoxication.

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第一作者： Brenna M,Flannery

第一单位： Department of Molecular Biosciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616, USA.

作者： Brenna M,Flannery ^[1] ; Donald A,Bruun ^[1] ; Douglas J,Rowland ^[2] ; Christopher N,Banks ^[1] ; Adam T,Austin ^[3] ; David L,Kukis ^[4] ; Yonggang,Li ^[5] ; Byron D,Ford ^[2] ; Daniel J,Tancredi ^[6] ; Jill L,Silverman ^[6] ; Simon R,Cherry ^[4] ; Pamela J,Lein ^[7]

作者单位： Department of Molecular Biosciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616, USA. ^[1] Center for Molecular and Genomic Imaging, University of California-Davis, Davis, CA, 95616, USA. ^[2] Current address: Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Sacramento, CA, 95812, USA. ^[3] Department of Pediatrics, University of California-Davis Medical Center, Sacramento, CA, 95817, USA. ^[4] Current address: Navistar, Inc., 2701 Navistar Drive, Lisle, IL, 60532, USA. ^[5] Division of Biomedical Sciences, University of California-Riverside School of Medicine, Riverside, CA, 92521, USA. ^[6] Department of Psychiatry and Behavioral Sciences, University of California-Davis Medical Center, Sacramento, CA, 95817, USA. ^[7] Department of Molecular Biosciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616, USA. pjlein@ucdavis.edu. ^[8]

关键词 Cognitive deficits Diisopropylfluorophosphate Neurodegeneration Neuroinflammation Organophosphate neurotoxicity PET imaging Sublethal effects TSPO