The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators.

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第一作者： Mohamed,Benchekroun

第一单位： Neurosciences Intégratives et Cliniques EA 481, Laboratoire de Chimie Organique et Thérapeutique, UFR SMP, Université Bourgogne Franche-Comté , 19 rue Ambroise Paré, CS 25000 Besançon, France.

作者： Mohamed,Benchekroun ^[1] ; Alejandro,Romero ^[2] ; Javier,Egea ^[3] ; Rafael,León ^[4] ; Patrycja,Michalska ^[3] ; Izaskun,Buendía ^[4] ; María Luisa,Jimeno ^[3] ; Daniel,Jun ^[4] ; Jana,Janockova ^[3] ; Vendula,Sepsova ^[4] ; Ondrej,Soukup ^[5] ; Oscar M,Bautista-Aguilera ^[6] ; Bernard,Refouvelet ^[7] ; Olivier,Ouari ^[6] ; José,Marco-Contelles ^[7] ; Lhassane,Ismaili ^[1]

作者单位： Neurosciences Intégratives et Cliniques EA 481, Laboratoire de Chimie Organique et Thérapeutique, UFR SMP, Université Bourgogne Franche-Comté , 19 rue Ambroise Paré, CS 25000 Besançon, France. ^[1] Department of Toxicology & Pharmacology, Faculty of Veterinary Medicine, Complutense University of Madrid , E-28040 Madrid, Spain. ^[2] Instituto de Investigación Sanitaria, Servicio de Farmacología Clínica, Hospital Universitario La Princesa , C/Diego de León 62, E-28006 Madrid, Spain. ^[3] Instituto de I+D del Medicamento Teófilo Hernando (ITH), Facultad de Medicina, Universidad Autónoma de Madrid , C/Arzobispo Morcillo 4, E-28029 Madrid, Spain. ^[4] Centro Química Orgánica "Lora-Tamayo" (CENQUIOR), CSIC , C/Juan de la Cierva 3, E-28006 Madrid, Spain. ^[5] Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence , CZ-500 01 Hradec Kralove, Czech Republic. ^[6] Biomedical Research Center, University Hospital Hradec Kralove , CZ-500 05 Hradec Kralove, Czech Republic. ^[7] ICR UMR 7273, Aix Marseille University, CNRS , 13013 Marseille, France. ^[8] Laboratory of Medicinal Chemistry, IQOG, CSIC , C/Juan de la Cierva 3, E-28006 Madrid, Spain. ^[9]