Targeting the hedgehog transcription factors GLI1 and GLI2 restores sensitivity to vemurafenib-resistant human melanoma cells.

导出 OA

翻译打印收藏纠错

第一作者： F,Faião-Flores

第一单位： Department of Clinical Chemistry and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.

作者： F,Faião-Flores ^[1] ; D K,Alves-Fernandes ^[1] ; P C,Pennacchi ^[1] ; S,Sandri ^[1] ; A L S A,Vicente ^[2] ; C,Scapulatempo-Neto ^[3] ; V L,Vazquez ^[4] ; R M,Reis ^[5] ; J,Chauhan ^[6] ; C R,Goding ^[6] ; K S,Smalley ^[7] ; S S,Maria-Engler ^[1]

作者单位： Department of Clinical Chemistry and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil. ^[1] Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil. ^[2] Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil.;Department of Pathology, Barretos Cancer Hospital, Barretos, Brazil. ^[3] Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil.;Department of Surgery Melanoma/Sarcoma, Barretos Cancer Hospital, Barretos, Brazil. ^[4] Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil.;Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal.;3B's - PT Government Associate Laboratory, Braga/Guimarães, Guimarães, Portugal. ^[5] Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Headington, Oxford, UK. ^[6] The Department of Tumor Biology, The Moffitt Cancer Center and Research Institute, Tampa, FL, USA. ^[7]