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首页> European journal of medicinal chemistry> Multi-targeting exploration of new 2-aminothiazolyl quinolones: Synthesis, antimicrobial evaluation, interaction with DNA, combination with topoisomerase IV and penetrability into cells.

Multi-targeting exploration of new 2-aminothiazolyl quinolones: Synthesis, antimicrobial evaluation, interaction with DNA, combination with topoisomerase IV and penetrability into cells.

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作者： Yu,Cheng ^[1] ; Srinivasa Rao,Avula ^[1] ; Wei-Wei,Gao ^[1] ; Dinesh,Addla ^[1] ; Vijai Kumar Reddy,Tangadanchu ^[1] ; Ling,Zhang ^[1] ; Jian-Mei,Lin ^[2] ; Cheng-He,Zhou ^[3]

作者单位： Institute of Bioorganic & Medicinal Chemistry, Key Laboratory of Applied Chemistry of Chongqing Municipality, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China. ^[1] Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu 610072, China. Electronic address: feiyu127@126.com. ^[2] Institute of Bioorganic & Medicinal Chemistry, Key Laboratory of Applied Chemistry of Chongqing Municipality, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China. Electronic address: zhouch@swu.edu.cn. ^[3]

关键词 Aminothiazole Antibacterial Antifungal Molecular modeling Quantum chemical studies Quinolone

主题词动物(Animals);抗感染药(Anti-Infective Agents);生物转运(Biological Transport);牛(Cattle);细胞系(Cell Line);细胞膜通透性(Cell Membrane Permeability);DNA(DNA);DNA复制(DNA Replication);DNA拓扑异构酶Ⅳ(DNA Topoisomerase IV);药物设计(Drug Design);动力学(Kinetics);小鼠(Mice);微生物敏感性试验(Microbial Sensitivity Tests);通透性(Permeability);喹诺酮类(Quinolones)

DOI 10.1016/j.ejmech.2016.10.011

PMID 27769037

发布时间 2017-09-22

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European journal of medicinal chemistry

935-945页

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